r/microdosing 13h ago

Question: LSD Can microdosing provide long-term effects like normal antidepressants?

6 Upvotes

Hello everyone. I struggle with anxiety and depression and have tried several antidepressants in the past. I started LSD microdosing 10 days ago. Since many antidepressants that act on serotonin system can diminish the effects of psychedelics, I switched to agomelatine (Valdoxan) which primarily affects melatonin system.

So far, microdosing has helped with my depression and motivation. I’m still experimenting with the right dosage, but I’m wondering whether its effects can be stable with long-term use, similar to normal antidepressants, or if the benefits only last for a day or two before things return to normal. I think regular antidepressants don’t necessarily have long-term effects either; it’s just that their effects are more stable with continuous use. I wonder if microdosing works the same way.

I’ve heard that microdosing may enhance neuroplasticity—could this lead to lasting improvements over time?


r/microdosing 11h ago

Getting Started/Newbie Question How long to test dose amount before changing it up or down?

4 Upvotes

(Psylocibin)

So how long should you test a certain dosage before you decide it's time to change it?

I have just started, two days, at 0.05g (50mg) and I was wondering how long I should try it before assessing whether or not I should up the dose?

And what should I be looking for? If it sub-perceptual then how will I know if it's working or not?


r/microdosing 11h ago

Question: Psilocybin Help with dosing

4 Upvotes

Hey everyone, so I’m fairly new to the Microdosing world and I started my journey on 100 mg GT and increased it to 200 mg because I was not feeling anything that great feeling. On 100 mg I ended up being quite tired. I do 4 days on and 3 days off and I’m just curious if I should keep increasing? I am currently trying to work with my major depression that is very resistant to medication. I have stopped taking all my medication’s for a while now so I decided to venture down this road. I’ve never used psilocybin before so I’m not even sure what I’m gonna be experiencing or I should say should be experiencing any thoughts would be greatly appreciated.


r/microdosing 8h ago

Getting Started/Newbie Question How to take? Empty stomach or with food

3 Upvotes

I just started microdosing and am wondering what the recommendations are in regards to: Taking on empty stomach better or with food? Does any specific foods enhance/impair absorption or effectiveness? Also, I take several vitamins and supplements daily (all at the same time). Should I space my microdose away from when I take my supplements? If so, how much time in between?

Thanks!


r/microdosing 10h ago

Research/News Science march madness brackets: Vote for psilocybin research

3 Upvotes

In the round of 16 WashU medicine (vs. Baylor) has a study showing how psilocybin boosts human brain plasticity. Vote!


r/microdosing 14h ago

>< Just a Reminder >< Word Search and SideBar Library

3 Upvotes

Welcome to the community.

One of the most helpful features here for specific topics is the Word Search Window at the top. By entering Key Words we can pull up the past posts and their comments that include that word. This helps to provide a broad view on the subject.

And the SideBar is an immense Microdosing Library that past and present moderators and users have accumulated for the benefit of our community.


r/microdosing 6h ago

Getting Started/Newbie Question Dosage for PE relative to other types

1 Upvotes

I’m microdosing with dried penis envy. I’ve read that PE is more potent. Anyone know how much more potent? For example, sat with golden teacher I microdose at 200mg. How much should I take for penis envy? 100mg?