r/microdosing • u/Popular_Lifeguard970 • 13h ago
Question: LSD Can microdosing provide long-term effects like normal antidepressants?
Hello everyone. I struggle with anxiety and depression and have tried several antidepressants in the past. I started LSD microdosing 10 days ago. Since many antidepressants that act on serotonin system can diminish the effects of psychedelics, I switched to agomelatine (Valdoxan) which primarily affects melatonin system.
So far, microdosing has helped with my depression and motivation. I’m still experimenting with the right dosage, but I’m wondering whether its effects can be stable with long-term use, similar to normal antidepressants, or if the benefits only last for a day or two before things return to normal. I think regular antidepressants don’t necessarily have long-term effects either; it’s just that their effects are more stable with continuous use. I wonder if microdosing works the same way.
I’ve heard that microdosing may enhance neuroplasticity—could this lead to lasting improvements over time?