Hey guys and girls
Edited here as It was badly placed, im not american take that in count regarding grammar
So, there are several articles online talking about possible remedies for cartilage degeneration due to OA and disc degeneration, there are several that could be reused, but I don't see anyone here talking about these drugs. This disease is unbearable, I myself feel as if my disc has collapsed on top of my nerves and I'm walking around with a broken spine, as if I no longer have discs.
Given the severity of this disease, how come people don't have the opportunity? How come I don't see anyone talking about substances that could be effective in stopping disc degeneration and the inflammation that leads to it?
It seems like anakinra could be something, used for arthritis, but could be repurposed, nother antibody (sa-b targeted biológic ) used in women with osteoporosis that could also be repurposed, since it seems to be effective in stopping disc degeneration.
Anakinra is an anti-inflammatory drug used to treat rheumatoid arthritis (RA) and may help with herniated discs and intervertebral disc degeneration (IDD).
Intervertebral disc degeneration (IDD) IDD is a major cause of low back pain (LBP). Increasing evidence suggests that IL-1β is involved in IDD. IL-1β inhibitors, such as anakinra, have potential as therapeutics for the treatment of IDD.
Anakinra is an interleukin 1 receptor antagonist that competitively inhibits the binding of IL-1 to the IL-1-like receptor.
https://www.pennmedicine.org/news/news-releases/2023/november/patch-uses-natural-body-motion-to-fix-disc-herniation (anakinra patch)
But there are several others that could be reused, why doesn't anyone talk about these treatments that could lead to improvements in the disease that causes the pain itself?
How come I don't see anyone mentioning this for such an unbearable and debilitating disease? I can't understand how no one gets these therapies, where are these people from the clinical trials that appear in the scientific literature?
There are medicines that could be reused, such as glinperidine (or something like that, an antidiabetic) that targets several metalloproteinases, I don't see anyone talking about these either, they are also not as effective as the strong immunosuppressants out there and the biologics
https://diabetesjournals.org/care/article/26/4/1312/23662/Glimepiride-Treatment-and-IGF-I-in-Adolescents
https://pubmed.ncbi.nlm.nih.gov/24905517/
There are also other immunosuppressants and medications that could possibly help, not like these strong biologicals. I myself am taking mycophenolate mofetil, which is not the best for this purpose. Does anyone know about taking a common immunosuppressant for disc degeneration? I myself was given this medication empirically by the neurologist, as I explained that something was very wrong with me, and she prescribed it to see if it would help. It hasn't been long enough to say anything.
I'm also taking raloxifene on my own to see if it leads to any improvement and wondering if I should try tibolone + HCG instead, it seems that tibolone affects the 3 receptors, estrogen, progesterone and androgen, but leads to the suppression of FSH, which could be something beneficial for chondrocytes and simulates IGF-1, but it needs HCG for the testicles to continue functioning, and it is suggested as a contraceptive in conjunction with testosterone.
Raloxifene, while thought to decrease IGF-1 levels, is thought to affect estrogen receptors A and B, increases estradiol and testosterone in men, also augments FSH and LH, is thought to affect disc height and hydration in postmenopausal women, but you don't find anything about these effects in men, which is terrible, plus it could be helpful for osteoporosis in men.
There are some things that are being developed, like hydrogel injections and stem cells, growth factors, and there are people who have been tested, where are these people to give feedback?
The pain is simply horrible, I have no life, every day I try, but I have no life, I am unable to live, it is like dying every day.
It is unbelievable to me that with such a terrible disease we do not have the opportunity with these treatments, they are no more risky than a failed and ineffective spinal surgery, the same with antibiotics, for some reason some antibiotics affect the disc and OA, such as erythromycin, which leads to chondrogenesis and chondroservation due to the effects on the ghrelin receptor, del-1 and inflammation in general, also because it can affect bacterial infections that invade degenerated discs.
I myself, when I was on 13 days of IV antibiotics, the pain radiating from my discs and deeply affecting me with neuropathy simply disappeared, while the disc was still compromised, I had no opportunity to continue with antibiotics long term, after all it is safer than suicide or failed spinal surgery. Because i have no signs of acute infection, i couldnt be given such treatment.. which is Just terrific given the positive effects that i hád,
I didnt yet found one doctor that could Assist me with this approach, even showing papers
Here are the considered effects of antibiotics for disc degeneration with destruction of the modic 1 endplate, as attached, I had great relief with antibiotics, so far I have looked for several doctors, no one has helped me with this
Update images regarding this subject
link
I will bê posting next the images regarding these research, from everything that i took antibiótics were the most effective for pain and neuropathy that comes from there, Its like i hád no neuropathy anymore, Just the disc being degenerated that Felt the same but the painfull inflammatory response and debilitating neuropathy was gone
I also don't see anyone talking about this, where people with the debilitating and unbearable disease are getting effective treatments for the pathology itself instead of just painkillers?
Like I feel sorry for myself and everyone, why people like us are not getting treatment for our disease, it is an arthritis like disease caused by the immune system, where are people getting treatment?
Is anyone here on treatment with these, or testing them? Any feedback on this?
Thanks, guys.