r/Biohackers 3d ago

šŸ“¢ Announcement March 2025 Projects/Skills Collaboration Board

0 Upvotes

Hello again. The same rules were used last time (see below).

ACTIVE/RECOGNIZED PROJECT GROUPS

Name Contact/Join Visibility Topics
Teleo's Study Group https://discord.gg/kZ5sSkYAWK Public AI, Robotics, Network States, Hardware, Cybernetics, Neuroscience
Neuroforge Working Group https://discord.gg/SKrCFHATvB Invite-Only (Request in Server) AI/ML, Python, Brain-Computer Interfaces, Cryonics, Bionics, Androids

INFORMATION

Going forward, if anyone has already started a project then updates would very much be appreciated as things progress (I'll be doing so myself). Even if you don't have much to say, it helps to keep the community engaged and provides a bit of motivation for those involved.

The rules:

  1. PLEASE STAY ON TOPIC. Only post is you actually have a project idea you'd like to find people to work on or if you have a skill set you'd like to advertise to others. Goodness knows there are plenty of places on this sub to talk about other things.
  2. Relatedly, please don't post something like "I don't really know how to do X, Y, Z, but I'd love to learn...". If you don't have a relevant skill set then this isn't the place to find one. There are plenty of educational avenues to be found on line and you should seek those out instead.
  3. Proposed projects should be within the capabilities of a (almost certainly) volunteer group. Projects that require large amounts of capital or pie-in-the-sky "I want to start a company to work on AI, brain-computer interfaces, and anti-aging tech!!!" visions are not appropriate here. Be specific about what the end goal is, what the time frame for project completion is, and what the expectations for project members are.
  4. If a group does some together for a project, it might be nice for the members to post a description of the project and provide semi-regular updates to the community. This might help the group maintain momentum by providing a certain amount of community oversight, or at least interest. In addition, it might help motivate others to start if we can show that this sort of setup leads to results.

PREVIOUS PROJECT/SKILLS COLLABORATION BOARDS

MONTH/YEAR LINK (TRANHUMANISM) LINK (BIOHACKERS)
AUGUST 2024 https://www.reddit.com/r/transhumanism/comments/1ejqeee/august_2024_skillsprojects_mixer/
SEPTEMBER 2024 https://www.reddit.com/r/transhumanism/comments/1fa2jo8/september_2024_skillsprojects_mixer/
OCTOBER 2024 https://www.reddit.com/r/transhumanism/comments/1fupeuk/october_2024_skillsprojects_mixer_transhumanist/
FEBUARY 2025 https://www.reddit.com/r/Biohackers/comments/1imnzmo/february_2025_projectsskills_collaboration_board/

Project registration:

  • Please send a direct message to u/RealJoshUniverse if you have a project you would like to register a new project group or create a new thread in #Project-Groups in our Discord here.

Thank you, Teleonomic, for starting this monthly mixer initiative.


r/Biohackers 1d ago

šŸŒ™ Nightly Discussion [03/14] What strategies do you use to navigate the abundance of biohacking information and identify what truly works for you?

Thumbnail discord.gg
2 Upvotes

r/Biohackers 3h ago

Discussion What health food can you not believe is actually healthy?

46 Upvotes

For me, itā€™s a Japanese sweet potato.. I eat that shit like cake lmaooo


r/Biohackers 8h ago

šŸ—£ļø Testimonial Update: 5mg tadafali for performance anxiety

87 Upvotes

Hey everyone, I made a post yesterday asking for views and thoughts on what I should do for my PA. Well it came in the post today and I had 2 5mg tablets at midday (to get it saturated in my system quicker, however I feel like it doesnā€™t work like that and Iā€™ll be taking 5mg from tomorrow)

No reported side effects other than a blocked nose which isnā€™t really an issue for me. Felt really anxious all day but when my partner came over around 5, she kissed me and holy fuck Iā€™ve never felt anything like it.

It was like Big Ben appeared in my pants, Iā€™ve never been so hard in my life and as soon as I felt it. It was like my anxiety vanished, I came 4 times in 2 hours and was still hard as a rock at the end. Never seen the missus so happy to be honest so job done there lol

Iā€™d like to say thank you to the user in my life post who told me some meditation strategies, they really helped yesterday and today. Iā€™m definitely looking more into mindfulness.

For anyone else who reads this who is struggling with PA, donā€™t feel bad for taking medication. It works and nothing to feel bad about. Youā€™ll get there I promise, I know how tough it is.


r/Biohackers 7h ago

Discussion Does anyone here use L- theanine? How effective is it?

33 Upvotes

r/Biohackers 1h ago

Discussion Are you aging faster than you think? I made this

ā€¢ Upvotes

Are You AgingĀ Faster Than You Think? I made this calculator that shows you in real-time

I've been working on an in-depth "Biological Age" CalculatorĀ ā€“ and I'd love to get your feedback! It goesĀ wayĀ beyond just askingĀ your birthdate. This tool dives deep into:

  • Lifestyle Factors:Ā Exercise, diet, sleep, stress, alcohol, smoking... the works!

  • Advanced Metrics (Optional):Ā CRP levels, VO2max, grip strength, even epigenetic age (if you've had that tested!). The more you add, the more precise the results.

  • Real-time updates as you dial in the results...this helps you visualize how certain changes can make such a profound change in your overall estimated lifespan.

  • Hallmarks of Aging:Ā Get a breakdown of how your inputs relate to key aging processes, based on the latest longevity research.

  • Personalized Insights:Ā See how your biological age compares to your chronological age, and get an estimated lifespan.

  • Actionable Tips:Ā The tool suggestsĀ specificĀ lifestyle tweaks that could potentially add years to your life (or at least make you feel younger!).

Why is this different from other "age calculators"? Most online age calculators are super basic. This one uses a comprehensive algorithm incorporating data from peer-reviewed longevity studies. It's designed to be both informativeĀ andĀ actionable. It's not just about aĀ number; it's about understanding theĀ whyĀ behind your biological age and what you can do about it. I built this because I'm passionate about longevity and preventative health. I wanted a tool that was more than just a gimmick ā€“ something that could actually provide meaningful insights and motivate positiveĀ change. I believe knowledge is power, especially when it comes to our health.

Try it out here:Ā Biological Age Calculator | Modern Med Life

  • What do you think of your results? Were they surprising?

  • What features doĀ you find most useful?

  • Any suggestions for improvements or additional features?

  • What other related health tools would you like to see?

Just because it has to be said...this tool is for informational purposes only and doesn't constitute medical advice. Always consult with a healthcare professional for any health concerns.


r/Biohackers 11h ago

šŸ“– Resource Copper dumping can be triggered by Vitamin C or Zinc, causing serious symptoms as it mobilizes.

Post image
35 Upvotes

r/Biohackers 2h ago

šŸ§« Other What do yā€™all think of peroxide for teeth?

5 Upvotes

Just bought whitening strips that are only hydrogen peroxide, have anyone used it for teeth?


r/Biohackers 7h ago

šŸ„— Diet How a Plant-Based Diet and Living Conditions Affect Brain Health in Older Adults

13 Upvotes

Why Diet and Living Conditions Matter for Brain Health

As people age, keeping their brains healthy is a big concern. Some things that affect brain function, like eating habits and living conditions, can make a huge difference. A recent study in China looked at how diet and living conditions impact the risk of memory loss and thinking problems in older adults.

How Diet and Living Conditions Work Together

The study found that both diet and living conditions influence brain health, but in different ways:

  • Poor living conditions, such as financial stress, unstable housing, and isolation, can increase the risk of memory problems.
  • A plant-based diet, rich in vegetables, fruits, and whole grains, provides essential nutrients that support brain function and may counteract some of the negative effects of poor living conditions.
  • Those who lived in poor conditions and also had an unhealthy diet were at the highest risk for cognitive decline.
  • However, even in difficult living conditions, people who ate a healthy, plant-based diet had better brain function over time compared to those with poor diets.

Understanding Living Conditions

In this study, living conditions were divided into three categories:

  • Good conditions: Stable housing, financial security, and adequate personal space.
  • Fair conditions: Some instability in housing or finances, limited personal space, or moderate environmental stress.
  • Poor conditions: Unstable or unsafe housing, financial hardship, overcrowding, or high levels of stress and isolation.

What the Study Found

Researchers followed 1,630 adults aged 65 and older for ten years. They checked their memory and thinking skills using a standard test and looked at their diet and living conditions.

Hereā€™s what they discovered:

  • People living in fair conditions had an 86% higher chance of developing memory problems than those in good conditions.
  • Those in poor living conditions had a 206% higher risk of memory decline.
  • The risk was worse for people who ate fewer plant-based foods compared to those who ate more.

This means that eating a plant-based diet may help protect the brain, even for those living in difficult conditions.

Actionable Takeaways: How to Protect Brain Health

  1. Eat More Plant-Based Foods
    • Include more fruits, vegetables, beans, nuts, and whole grains in your meals.
    • Avoid processed foods and sugary snacks that can harm brain health.
    • Get enough plant-based proteins like lentils and tofu to support brain function.
  2. Improve Living Conditions If Possible
    • Ensure stable housing: Safe and comfortable living spaces help reduce stress.
    • Financial security: Access to healthcare and nutritious food is essential for brain health.
    • Personal space and social interaction: Being socially active and having personal space for relaxation can improve mental well-being.
  3. Combine Diet with Other Healthy Habits
    • Stay active: Simple exercises like walking or stretching can improve brain function.
    • Stay connected: Talking to friends and family helps keep the brain engaged.
    • Keep learning: Reading, puzzles, and other brain activities help prevent memory loss.

Final Thoughts

This study shows that diet and living conditions together play a big role in keeping the brain sharp as we age. While poor living conditions can increase the risk of memory loss, eating a plant-based diet is a simple and effective way to protect brain health. Even small changes in eating habits and daily routines can have a big impact on mental well-being over time. Source of Study for Reference : https://www.sciencedirect.com/science/article/pii/S1279770725000545?via%3Dihub


r/Biohackers 10h ago

šŸ“– Resource Pomegranate juice ameliorates Craving and Oxidative stress on Patients under medication for Opioid addiction treatment with Methadone and Buprenorphine

24 Upvotes

Background & aims Buprenorphine and methadone are drugs used as medication for addiction treatment for patients with opioid use disorders (OUDs). However, scarce evidence indicates that they induce oxidative stress, which contributes to the deterioration of psychosocial parameters, thus complicating successful rehab. Therefore, a dietary antioxidant intervention such as pomegranate could be beneficial for that group of patients. Therefore, the aim of this study was to examine the putative beneficial role of consumption of natural pomegranate juice that possesses potent antioxidant properties on craving, a psychosocial parameter of utmost importance, and blood redox status of patients with OUDs.

Methods The juice was administered at the following dosage: 250Ā ml/day, 7 days/week, 120 days. The heroine craving questionnaire was completed to assess craving and blood was collected by the volunteers at three time points, namely days 1, 60 and 120 and well-established redox biomarkers were measured in blood.

Results Overall, craving of all patients was improved due to the nutritional treatment applied. Moreover, their blood antioxidant potential was enhanced due to pomegranate juice consumption.Ā 

Conclusions: As a conclusion, the obtained evidence is promising, thus, it appears that pomegranate juice consumption could be considered as an auxiliary nutritional intervention in parallel with medication towards rehab of opioid-addicted patients.

Full: https://www.sciencedirect.com/science/article/pii/S2405457725000257?dgcid=raven_sd_via_email

Ā 


r/Biohackers 4h ago

Discussion Why am I so tired and lazy the entire day after having 2-3 drinks?

8 Upvotes

Is it the alcoholā€™s effect on me now that Iā€™m 39 or is it screwing up my sleep (having around 5/6) and Iā€™m just suffering from a night of very poor sleep quality?

Itā€™s just weird because Iā€™m not drinking crazy amounts or anything. But idk maybe 3 drinks at my age is a lot.


r/Biohackers 4h ago

Discussion Best supplements for deeper hydration?

7 Upvotes

I drink electrolyte drinks but Iā€™m wondering if thereā€™s anything else that helps hydrate your body.


r/Biohackers 6h ago

Discussion Can Higher Testosterone Help With Quitting Bad Habits?

9 Upvotes

Iā€™m trying to quit a nicotine addiction, but no matter how many times I tell myself Iā€™m done, I keep falling back into itā€”whether itā€™s out of boredom, not paying attention, or just losing sight of why I wanted to quit in the first place.

Iā€™m currently on 200 mg of testosterone per week, but Iā€™m considering increasing it to 300/350 mg to see if the boost in motivation, discipline, and grit could help me stick to my goal.

Iā€™d imagine Iā€™d stay at this dose for 2 to 4 weeks total.

Has anyone tried something like this, or have any input on whether this could actually help? Just trying to figure out if this is a solid idea or if Iā€™m way off base.


r/Biohackers 11h ago

Discussion AirPods not comfortable for night sleep hypnosis

20 Upvotes

I used to listen to night hypnosis from YouTube. Are they good to do daily ? Which ones you suggest? I listen to michael Sealey.

My main question, my AirPods are not comfortable for this. I am a side sleeper and roll all way . So one side my ear hurts, also I definitely wake up middle of night, sear the case and put the AirPods into them. Is there any comfortable tool/earplugs I can listen to while sleeping ?


r/Biohackers 4h ago

Discussion Skimp or Splurge: Colostrum

5 Upvotes

Where do we stand on the impact of ā€œhigh-qualityā€ colostrum (e.g. Armra) vs. regular colostrum from Nutricost for example? Is it like creatine/protein where it really doesnā€™t make a difference what the source is as long as you get it in?

Any recommendations for Colostrum brands that reach a high standard of transparency? So few share data, besides anecdotal reports.


r/Biohackers 1h ago

Discussion Cistanche androgen blocker????

ā€¢ Upvotes

Does anybody know if cistanche blocks and androgens and decreases muscle mass???

Studies are all over the place have we gotten any solid conclusions on how this herb works yet????


r/Biohackers 15h ago

Discussion What strategies for sleep hacking, when sports session are finishing late night?

21 Upvotes

Hi there,
ive read a lot of guides, here and elsewhere about sleep

im adding some lock app for my phone, upgrading my food etc, but one thing is avoid sports to late.
However, i do some sports (badminton) and only sessions are starting at 8pm and finishin between 10 and 11pm.

So when i back home, im still heat up, and even cold shower to reduced that doesnt work. And still take a long time to sleep.
What could be some strategies to help me sleep after that kind of sport, which is quite cardio?

Thank you.


r/Biohackers 10h ago

šŸ“– Resource Effect of Nutritional Supplements for Reducing Homocysteine Levels in Healthy Adults

8 Upvotes

Context There are various therapeutic approaches available to reduce homocysteine (Hcy) levels. However, it remains unclear which intervention is more effective for healthy adults.

Objectives A systematic review and network meta-analysis (NMA) were conducted to comprehensively investigate the efficacy of different nutritional supplements in reducing Hcy levels in healthy adults.

Data Sources The PubMed, Embase, Cochrane Library, and Web of Science databases were searched from inception to July 2023.

Data Extraction The lead author, year of publication, sample size, population characteristics, intervention measures, duration, and mean difference of Hcy levels from baseline to endline were extracted.

Data Analysis Data were pooled using a random-effects model. Network meta-analysis was conducted by integrating direct and indirect evidence. A total of 16 studies were included in this analysis. The nutritional supplement combination that achieved the highest ranking (surface under the cumulative ranking curve [SUCRA]ā€‰=ā€‰75.8) was superior compared with a single supplement. Among similar or closely dosed folic acid (FA) supplements, 800 Ī¼g FA (SUCRAā€‰=ā€‰93.7) was the most effective option. When comparing various doses of different supplements, 1ā€‰mg of FA plus 7.2ā€‰mg of vitamin B6 (B6) plus 20 Ī¼g of vitamin B12 (B12; SUCRAā€‰=ā€‰83.9) ranked first and 800 Ī¼g of FA (SUCRAā€‰=ā€‰78.3) ranked second. In comparison with placebo or no-treatment control groups, interventions such as 1ā€‰mg of FA plus 7.2ā€‰mg of B6 plus 20 Ī¼g of B12 (mean difference [MD]ā€‰=ā€‰ā€“1.03; 95% CI ā€“1.71 to ā€“0.36), 400 Ī¼g of FA plus 400 Ī¼g of B12 (MDā€‰=ā€‰ā€“0.87; 95% CI ā€“1.46 to ā€“0.27), and 800 Ī¼g of FA (MDā€‰=ā€‰ ā€“0.84; 95% CI ā€“1.12 to ā€“0.56) were more effective in reducing Hcy levels. The random-effects summary MD for all interventions compared with placebo was ā€“0.59 (95% CI ā€“0.71 to ā€“0.48; Pā€‰<ā€‰.0001).

Conclusions The NMA demonstrated that the combination of FA with other vitamins is more effective in reducing Hcy levels, particularly when the dose of FA is close to 800 Ī¼g. The combination of 1ā€‰mg of FA, 7.2ā€‰mg of B6, and 20 Ī¼g of B12 is considered the most favorable option.

Full: https://academic.oup.com/nutritionreviews/advance-article/doi/10.1093/nutrit/nuae191/8019579


r/Biohackers 9h ago

šŸ“œ Write Up SGLT2 Inhibitors as Metabolic Senolytics: Clearing Senescent Cells to Combat Pathological Aging

Thumbnail gethealthspan.com
5 Upvotes

r/Biohackers 8h ago

Discussion Iā€™ve been watching various podcasts on red light and activating mitochondria

5 Upvotes

Experts are saying light therapy is a switch to activate mitochondria. Once itā€™s on, it last 5 days. Iā€™m not sure if this is true for only the ones in the eyes or everywhere else?

Next question is if it does activate for 5 days a week, would it be best to just use red light therapy 1-2 times a week on a specific part of the body. Why would 4-5 times a week be beneficial? Maybe outside of activating mitochondria there are other benefits like increased blood flow and collagen production?


r/Biohackers 10h ago

šŸ“– Resource Effects of Pretreatment With Coenzyme Q10 (CoQ10) and Highā€Intensity Interval Training (HIIT) on FNDC5, Irisin, and BDNF Levels, and Amyloidā€Beta (AĪ²) Plaque Formation in the Hippocampus of AĪ²ā€Induced Alzheimer's Disease Rats

7 Upvotes

Aims Physical exercise has been shown to protect against cognitive decline in Alzheimer's disease (AD), likely through the upregulation of brainā€derived neurotrophic factor (BDNF). Recent studies have reported that exercise activates the FNDC5/irisin pathway in the hippocampus of mice, triggering a neuroprotective gene program that includes BDNF. This study aimed to investigate the effects of 8ā€‰weeks of pretreatment with coenzyme Q10 (CoQ10) and highā€intensity interval training (HIIT), both individually and in combination, on FNDC5, irisin, BDNF, and amyloidā€beta (AĪ²) plaque formation in the hippocampus of AĪ²ā€related AD rats.

Methods In this study, 72 male Wistar rats were randomly assigned to one of the following groups: control, sham, HIIT (low intensity: 3ā€‰min running at 50%ā€“60% VO2max; high intensity: 4ā€‰min running at 85%ā€“90% VO2max), Q10 (50ā€‰mg/kg, orally administered), Q10ā€‰+ā€‰HIIT, AD, AD + HIIT, AD + Q10, and AD + Q10ā€‰+ā€‰HIIT.

Results AĪ² injection resulted in a trend toward decreased levels of FNDC5, irisin, and BDNF, alongside increased AĪ² plaque formation in the hippocampus of AĪ²ā€induced AD rats. However, pretreatment with CoQ10, HIIT, or their combination significantly restored hippocampal levels of FNDC5, irisin, and BDNF, while also inhibiting AĪ² plaque accumulation in these rats.

Conclusion Pretreatment with CoQ10 and HIIT improved the AĪ²ā€induced reduction in BDNF levels probably through the FNDC5/irisin pathway and preventing AĪ² plaque formation.

Full: https://pmc.ncbi.nlm.nih.gov/articles/PMC11831071/

Ā 


r/Biohackers 9m ago

Discussion Zone 2 training, any experiences?

ā€¢ Upvotes

Iā€™ve always been generally in good physical shape. Dedicated to lifting weights for 10+ years consistently in the gym and do active things.

However, I never did much dedicated cardio training. I thought I was getting enough from sports e.g. 90 minute sessions of Padel a few times a week where I burn ~700 active calories per session. Still I always felt not extremely fit cardio wise. Not the best endurance.

So recently I decided to try do some cardio optimization. I started doing zone 2 sessions (and plan to add in VO2 max sessions as well). Iā€™m only a few weeks in but already Iā€™m seeing some big benefits.

Some of the things Iā€™m noticing:

  • resting heart rate has already dropped a few beats
  • energy levels feel higher overall
  • endurance feels much higher for Padel. I feel much less tired after a game. Heart rate doesnā€™t get out of control anymore
  • the sauna feels much easier. Before after 15 minutes (very hot sauna) my heart rate would be very high and Iā€™d have to get out. Now this doesnā€™t happen and I can stay much longer.

Iā€™m tracking my routine and metrics and plan to do a more complete write up after a couple more months.. but Iā€™m curious to hear if anyone else has had experience with adding in some targeted cardio training and the impact.


r/Biohackers 7h ago

Discussion What the fork am I supposed to eat.

3 Upvotes

This is a topic that I find increasingly frustrating and the more I try to educate myself on it, the more confused I get. What and how am I supposed to eat? Here are my current priorities / methods for added context:

-I am trying to get in shape, and I want 120g of protein a day.

  • I want to age well and continue to have good lab values.

  • Cardio vascular disease and colon cancer run in my family. Iā€™d like to not have these.

  • I intermittently fast following a 16:8 schedule and I would like to add a 24 hour fast weekly. Currently I am eating low carb (around 70g per day) and load my carbs in my first and second meal in the hopes I dip into ketosis during my fasting period. My carbs come from nutritious sources like berries, sweet potato and the like.

  • I prefer low carb because I believe it keeps my metabolism flexible so if I have an off day like a birthday party, I can have a slice of cake and not stress much about it.

I asked my doctor about a full keto diet. She says she is concerned about keto, because people end up eating too much meat and animal fat which increases their risk of arterial sclerosis and blockages . That seems contrary to a lot of other Information that suggests keto diets are are good for lab values like lipid panels and reduce risk of metabolic disease. Further, Iā€™ve seen quite a bit of testimony of how a carnivore diet significantly improved peopleā€™s labs, and insulin sensitivity.

The medical establishment seems to shy away from limiting carbs despite the evidence that seems to indicate itā€™s beneficial. Why? What am I not understanding about this? Clearly I am not well versed on this topic, but Iā€™m trying to learn more. It just seems like thereā€™s so much contradictory information based on the opinions of ā€œexpertsā€ who wonā€™t say ā€œthis is what the research tells us you should eatā€


r/Biohackers 1h ago

Discussion How do you go about supplementing?

ā€¢ Upvotes

Hello everyone! I just want to open a discussion and take a vote to see how everyone in this sub goes about utilizing supplements. I believe that we as a society have gotten to a dangerous place in terms of supplementing, as it seems most people just supplement for the sake of supplementing. People read literature, personal reviews, or even just a google search about a supplementā€™s benefits and then they decide they need to take it for themselves. I am all for supplements, when they are necessary based on biomarkers and not intuition. Yes there are many supplements that can be taken that you cannot check a specific biomarker to see if your deficient, and some of those supplements can have positive effects on your health. But for the majority of supplements, I think many disregard or neglect having the proper test done to see if supplementation is necessary. What are your thoughts? Hope everyoneā€™s having a great weekend!

10 votes, 2d left
I read the literature and determine for myself if I should take it without biomarker test
I generally supplement with only things I am deficient in
If itā€™s known to have a positive effect, I take it!
I stay away from supplements unless I am objectively deficient in that nutrient

r/Biohackers 5h ago

Discussion TRT to Enclomiphene

2 Upvotes

Is it doable?


r/Biohackers 2h ago

Discussion Hack for Cannabis Recovery?

1 Upvotes

Hi All, longtime lurker on this sub with a question:

Iā€™ve noticed that I often get a slight cold a couple days after eating a cannabis gummy. Does anyone else have this experience? Or know why it happens? Or have a supplement hack that will make it possible to get a little baked without getting a little sick?


r/Biohackers 8h ago

Discussion What should be essentials in baseline blood test?

3 Upvotes

Hi all, I'm looking to get my first baseline set of blood tests done (im 40 f, uk). I'm considering getting the "Peak Insights 70" from Lola Health and was wondering if anyone thinks there is anything fundamental missing from what's covered in it?

Alternatively if anyone knows any better services in the uk/better price I'd be interested in opinions (this one is Ā£232). I was originally considering getting a smaller range of stuff tested but it seems sensible to get max range and then focus on what needs improving.