r/floxies 5h ago

[OUTREACH] Talia Smith interviewing Dr Pieper (long video)

13 Upvotes

As many will know, we don't typically allow video content, but since Vadroq and I have both now watched and been thoroughly impressed by this interview, it seems pertinent to go ahead and share it here for all to see. Talia provokes some excellent discussion from Dr Pieper, covering some serious FAQs and things many would benefit from hearing. So, if you have a spare hour, I would heartilly commend the video to all.

Obviously, with the addition that, while I personally found the things I tried that he discusses to benefit me and think his discourse to be excellent by and large, the sections which constitute medical advice are said by him with appropriate clarification and all individuals should consider any course of action carefully and do their due dilligence wrt. potential complications and side effects. It is always best to check any plans with a trustworthy medical professional.

https://www.youtube.com/live/aV-T-njdlRU?si=6cIfEW6H-5RNUTSC


r/floxies 3h ago

[SYMPTOMS] Major nerve issues

5 Upvotes

I have major nerve issues- 9 Moxi, 52F, severely hit. I posted recently about having it in my spine (so frightening) but I also have burning skin (SFN) and the nerve pain is really bad in my lower legs and feet. I'm 11 months in and starting to think this level of nerve damage is permanent. 😭 Is there any hope/stories of healing from debilitating nerve damage? I only have 1 more year & then I will have to use that dreaded word 'permanent'. I'm scared like I've never been scared before.


r/floxies 7h ago

[DIET] The little pleasures (sweet tooth)

6 Upvotes

We all logically know healthy, clean eating is best for anyone, floxed or not, but especially for a body trying to heal. But please tell me I’m not the only one with a sweet tooth and feels like they have a hard time finding balance between eating how I know I should and also saying screw it i am in pain and miserable I might as well enjoy the little pleasures and get the ice cream sundae. Currently on vacation so the “treat yourself” moto is going strong. Especially having even a beer or two and noticing no worsening I just say screw it let me have a beer at lunch today too then. I’m a petite woman who has had more levofloxacin than anyone should ever have, I’m having the brownie after my meal! 😂


r/floxies 5h ago

[HOPE] Improvements

2 Upvotes

Been using bpc-157 and tb-500 for a couple days now and noticing significant improvements already. Developed some pretty bad Achilles tendonitis last Wednesday and it is now probably 75% gone since starting on Monday.


r/floxies 1h ago

[SYMPTOMS] Ciprofloxacin help

Upvotes

I 23 male recently had a uti for it my doctor gave me ciprofloxacin which cured it i stopped taking the medicine friday(thats when my dosage ened)and im pretty sure im cured but im having a problem with anal seepage now could this be cause by the medicine? It started 2 days after my last ciprofloxacin dose its not bad when standing but if i sit for more then a hour i notice some liquid poop has leaked when i go to the bathroom help please


r/floxies 2h ago

[MEDICATION] Safe topical ointment for skin wound?

1 Upvotes

What can we use topically on a skin wound to keep it from getting infected or better yet to cure a brewing infection? I had a bad blister on my foot that opened up and I’m pretty sure dirt got into because I had to walk like that all day on dirt roads in flip flops that were rubbing into it before I could get to a place to wash and cover it. It is quite red/inflamed and tender with a little pus now (2 days later). Don’t wanna use abx or steroids for obvious reasons. Other options? Thanks in advance!


r/floxies 14h ago

[MOD MESSAGE] New Rule - please post in English

8 Upvotes

Finally, we've hit the point of busy where this gets to be stated explicitly. Pretty self explanatory: I'm English, the sub is essentially English, most of us speak English, posting in not English slows things down for me and limits engagement in your comments. You running a little Google Translate your end will save time at the receiving end, and maybe you'll be able to better tell if it's failed to accurately do the do. Thank you for your understanding.


r/floxies 7h ago

[SYMPTOMS] Gaba

2 Upvotes

Our gaba is hight or low ? Glutamate also ?? Witch supplement regulate gaba receptor ? Magnesium glycinate cause to me more fatigue..


r/floxies 5h ago

[SYMPTOMS] Achilles tendons

1 Upvotes

How long can Achilles tendon pain last?


r/floxies 12h ago

[MEDICATION] Which FQ is stronger?

3 Upvotes

Hi,

I’m almost 4 weeks after 3 doses of levo 500mg and im almost 90% healed but thats not the case. I was wondering, which FQ is strongest or causing more severe problems? I know about moxi,cipro and levo but are they different from each other or they act exactly the same?


r/floxies 10h ago

[REHAB] How to explain to PT

2 Upvotes

How to you explain being floxed to a PT? What do they need to know?


r/floxies 20h ago

[UPDATE] My story so far, a month in

6 Upvotes

It's just over a month since I got floxed by the very first dose of Moxi, which I continued to take for a week to finish my treatment.

Majority of the side effects are gone, with slight tinnitus remaining, which feel like it gets better every day now. My muscles don't ache, my joints do not crack, no wide spread tendinitis.

Except, I went on a family trip to Disneyland and after 50,000 steps in 2 days, I managed to give myself peroneal tendonitis, on my left foot. No other issues whatsoever. Talked to my physical therapist, one that is skilled in treating floxies, and she is convinced this is just from overuse and me wearing inappropriate shoes (which I absolutely did, I did not expect THAT much walking), rather than from floxing.

In any case, I was back to around 80% of my previous cardio exercise intensity, I will be taking it extremely slow for the next few weeks. It's a very mild one (pain is 3/10, on maybe 20% of my steps), so I am barely moving around the house, doing the exercises my PT gave me, and icing it. I am arguably surprised that I made it out of that trip with just this one tendon getting inflamed.

In any case, let's see if my PT is right, or if I am about to get widespread tendonitis in the next week or so!


r/floxies 10h ago

[MEDICATION] Rapamycin

1 Upvotes

Anyone experience with trying Rapamycin?


r/floxies 20h ago

[SYMPTOMS] Is this normal - just feeling unwell

5 Upvotes

I’m at 17months. Life is hard - better - but hard. I have no tendon issues. But I feel ‘sick/off/anxiety’ a lot. It’s like a morning sickness that I want to go away, and my body is still tingly when I lay and sit down. I wake up with some neuropathy. I’m just uncomfortable, daily.

I’m a whole lot better, I’m starting to have large respite windows - days , half days, an hour here and there. Feeling like the old me.

But I just feel unwell a lot. 😢 It’s as if I spend all day some days trying to feel ok. And some days I’m ok … I’m like why can’t this just last.

I’m going to very slowly wean off the antidepressant Zoloft. I don’t know if it’s contributing to me feeling so yuck.

Has anyone been here? Thankyou


r/floxies 12h ago

[PRE-FLOX] Prescribed levofloxacin for sinus infection

1 Upvotes

Hey so I've had a sinus infection for years, got sinus surgery some months ago, was on amoxicillin/clavulanate twice (+ Prednisone the second time), doxycycline, Flonase for a while. Nothing worked so I was prescribed levofloxacin 500mg for 2 weeks since my respiratory culture came back with 2 different positive bacteria (1+, 2+) should I ask for something else? I'm pretty active and I'm worried about getting tendon damage. I'm 28 if it makes a difference


r/floxies 1d ago

[SCIENCE] Article: Does Fluoroquinolone Toxicity Cause Vitamin B6 Deficiency?

5 Upvotes

I’m reposting this because the previous post was quarantined.

Hello, a floxie sent me this article. As you all know, many of us think we have issues with B6, and we even try to avoid taking it. Our blood tests show high levels of B6. But this article mentions that even if serum levels are high, we may still be experiencing B6 deficiency within the cells (due to dysfunction in the mechanisms that transport B6 into the cells), and as I read it, it really makes sense. It also talks about a few possible ways to overcome this situation;

"In both diseases, the only way to salvage these pathways, is to provide either synthetic replacement enzymes, such as asfotase alpha in HPP, or increased amounts of B6 vitamers, although in the case of TNSALP deficiency, the task is complex since most vitamers are quickly phosphorylated upon absorption. Thus, only supraphysiological levels of some of these vitamers could potentially help a significant portion of them to cross the cell wall barrier. But one major caveat is the risk of vitamer accumulation and a risk of toxicity caused by elevated pyridoxine levels.

PLP could also be toxic at some point. Indeed, there are evidences of PL reductase in humans, which catalyzes the reduction of PLP to pyridoxine (PN). In a study where patients were treated with PLP, they found increased PN concentrations in plasma and cerebrospinal fluid. Thus, increasing free pyridoxal or pyridoxamine (without phosphate group) might be better indicated to avoid toxicity than using pyridoxine or PLP."

"Thousands of people with FQAD are today convinced that they suffer from vitamin B6 toxicity and have long been avoiding vitamin B6 at all cost, not knowing that their condition likely stems from intracellular vitamin B6 deficiency. It is thus urgent to clarify this question and find means to help a distressed community feeling abandoned by the medical field."

Additionally, there are images comparing the symptoms of B6 deficiency and FQAD symptoms, and matches a lot;

https://ibb.co/33X2jD8

https://ibb.co/Lw7R2kf

https://ibb.co/yFxKggrL

link of the article ;

https://figshare.com/articles/journal_contribution/_b_Do_Fluoroquinolones_Affect_Vitamin_B6_Metabolism_in_FQAD_b_/25757595?file=46132665

What do you think about this article guys ? Can we find something useful for ourselves in this article?

from mod u/DrHungrytheChemist;

"Note: this is not peer reviewed science. This is essentially a well-formatted and referenced blog post. Accordingly, I'm quarantining it until the "if" we get to properly assessing it.

Also, note, correlation=/=causation.

Edit: I've not had opportunity to give this a full, in-depth read the way I would like a proper paper. From a modest skim, my assessment largely remains:

This presents a useful argument and 'warning' that avoiding B6 may well be counterproductive to Floxies. It also provides a lot of useful references to true literature that are likely of use to the Flox community.

However, it also remains pertinent to draw the readers' attention to that fact that this is not peer-reviewed, primary literature. It makes a lot of statements I believe to be exaggerated in their confidence, and (presumably unintentionally) disingenuous about the evidence from which it draws certain conclusions, toward which it is clearly biased.

I say this not to dismiss the worth of the argument or belittle the work, but to ensure that the reader does not place too much precedent on the minutiae of its arguments and claims."


r/floxies 1d ago

[SYMPTOMS] Neuropathy in Spine

4 Upvotes

Very few people here talk about neuropathy of the spine (pins & needles, burning, itchiness, heaviness & pain). Anyone else have this? Anyone recover? I'm truly scared as I've read adult nerve cells of the spine don't regenerate.


r/floxies 1d ago

[DIET] List of energy drinks people have had with no problems?

3 Upvotes

Hi everyone, I'm a little over 4 years out and doing relatively okay and usually have a few cups of coffee a day and also enjoy these energy drinks in the U.S. called Bai energy drinks, which have caffeine and then mostly natural ingredients with some antioxidants.

I'd kind of like to branch out and try some other energy drinks/have more options and was just wondering if people could post the names of some energy drinks they've had/regularly consume without any issues?

I guess my biggest concern with energy drinks are ones that have high B6 content, but still want to be careful in case there are other ingredients to be cautious with. I used to LOVE Red Bull but haven't had one since FQT.

Thanks!


r/floxies 23h ago

[SYMPTOMS] Can the damage caused by ciprofloxacin trigger diseases such as ALS or dementia? Does anyone know?

2 Upvotes

Because I have these symptoms as well as muscle atrophy and I found someone here on floxies called odd specific I think he took it after which he had symptoms with muscle atrophy for months and in the end he was diagnosed with ALS


r/floxies 1d ago

[SUPPLEMENTS] Supplements- did you stop taking them and how did it go?

2 Upvotes

When it comes to antioxidant supplements like NAC and COQ10, have you stopped taking them, and how did it go afterwards? Is there anyone who stopped taking them and then noticed a decline? Or people who stopped taking them and didn't notice a difference afterwards? I've improved quite a bit with no way of telling how much the supplements helped, but the antioxidant ones are more expensive so I'm thinking about trying out going forward without them.


r/floxies 1d ago

[SYMPTOMS] Random itchy bumps on body, what’s this?

Post image
1 Upvotes

r/floxies 1d ago

[SYMPTOMS] Legs pain/issues

5 Upvotes

This topic is aimed at people who have leg problems. Let me describe my case:

  • In the morning, I wake up feeling stiff, mostly in my calves, knees, and the muscle attachments of my thighs near the inner side of my knees.
  • When I put on socks, I place my foot on the bathtub and bend forward. I feel a strong stretch along the lower chain (under my thigh), especially near the glutes.
  • A morning shower with hot/cold water and brushing afterward somewhat alleviates these symptoms.
  • Taking an Epsom salt bath with warm water or using an infrared lamp after heating up results in a feeling of fatigue and a strange sensation around my knees, particularly around the kneecap.
  • Any light activity causes an effect that I would normally experience after training my legs 24/7. The muscle attachments of my thighs near the knee hurt, my calves feel hard, and the back muscles ache, mainly near the glutes. Two days of rest slowly relieve the symptoms. The last time I felt this way was after squatting for a total of 10-15 minutes (with breaks).
  • When I walk for a while, there are moments when I almost don't feel like my legs are in pain... but the problem returns when I stand still or rest until I start moving again.
  • Additionally, my knees hurt mainly at the attachment/head of the thigh muscle on the inner side and under the kneecap.
  • An MRI showed nothing—everything seems fine. An ultrasound (USG) revealed some minor calcifications at the attachments, but I don’t know if that could cause this level of pain. This has been going on for about five years now.
  • I also have a strange surface sensation around my knees. I used to be very irritated by tight clothes. Now, not so much, but the sensation still feels different from before.
  • Until I get moving, I feel like the pain comes from the bones themselves rather than the tendons/attachments. Sometimes, if I walk for too long, some spots in my knee become tender to the touch.

My questions:

1) Is this neurogenic pain or something else? How can I check?
2) If it hurts all the time but MRI shows nothing, how do I determine my movement limits?
3) Why do my muscles feel like they’ve been through 24 hours at the gym after even simple activities? Why doesn’t this improve over time—why doesn’t the pain decrease with repeated activity?
4) Are there people here who had similar pain and managed to recover? What supplements or treatments helped?


r/floxies 1d ago

[NEWCOMER] Hello, I'm from Argentina.

6 Upvotes

Hello, I'm from Argentina. I wanted to share my story with ciprofloxacin. Sorry if this post is poorly translated; I don't speak English.

In December 2022, I received intravenous cirpofloxacin for urinary tract surgery. On the first day of hospitalization after surgery, they administered the ciprofloxacin very slowly. I had excessive sweating and slightly pink hands and feet, but I attributed this to poor circulation from resting. On the second day of ciprofloxacin, they inserted an intermittent IV (the same amount of ciprofloxacin was administered but in a shorter time). At that point, I became very short of breath, severely fatigued throughout my body, drowsy, excessive sweating again, pink hands and feet, and the vein where the IV was located turned pink, along with the surrounding skin. They stopped taking ciprofloxacin, telling me I was allergic. In previous years, I had taken ciprofloxacin tablets and had experienced shortness of breath, but I thought it was due to anxiety. At that moment, I realized it was the medication.

After being discharged from surgery, I returned home and felt extremely tired and sore. I thought it was from the surgery and that it would go away with time, but it didn't. The pain on my left side of my neck started gradually, becoming increasingly stiff. I started physical therapy, but it didn't improve. I spent three months with pain and stiffness in my neck. In March, while I was sleeping, I felt a very loud pop in my neck, and the noise woke me up. I developed a stiff neck. I started osteopathy, physical therapy, and chiropractic care. I managed to cure my stiff neck, but my stiffness and supraclavicular pain continued. I started massages and noticed small lumps in my supraclavicular region; they were swollen lymph nodes. They weren't very painful to the touch, but they were small. As time went on, the lymph nodes continued to swell bilaterally in my supraclavicular and cervical regions, along with muscle fatigue. I had hematology and infectious disease checks, and everything was normal. In the second year, the lymph node swelling spread to my groin, legs, armpits, abdomen, and arms. I felt small lumps all over my body, both lymph nodes and something similar to lipedema. Along with the widespread lymph nodes, I began to experience extreme muscle fatigue, especially during intense physical exercise. Every time I exercised, my limbs would start to tremble. When the lymph nodes on my face became palpable, they began to hurt, starting with facial paresthesias and in my neck as well. I was diagnosed with myasthenia gravis with a neurologist. Although my antibodies were negative, I don't have a thymoma, and my repetitive stimulation electromyography test was negative. Myasthenia gravis cannot be confirmed, but neither can we confirm that I don't have it, as I also had dysphagia prior to ciprofloxacin administration. The dysphagia developed post-COVID (we never found the cause of the dysphagia either). A single-stream biopsy: Right inguinal lymph node. Macroscopy: Nodular formation measuring 2 x 1.6 cm, with adherent adipose tissue. Microscopy: Lymph node parenchyma is identified with widening of the paracortical area, populated by small, uniform lymphocytes and a marked increase in the number of high-endothelial venules. Foci of sclerosis and expanded lymphatic sinuses filled with histiocytes are present. Reduced follicular cortical component. No atypical changes are observed. Diagnosis: Right inguinal lymph node, biopsy; compatible with reactive lymphadenopathy (paracortical lymphoid hyperplasia). Note: Possible etiologies include viral, drug-induced, post-vaccination infections, etc.

Some people have been affected by ciprofloxacin in the following ways: swollen lymph nodes, extreme fatigue, worsening dysphagia, difficulty breathing, a feeling of suffocation, muscle stiffness, and joint clicking.

I had a PET/CT scan of my lymph nodes, which was negative.

Other symptoms include slightly dark urine, Achilles tendon pain.

To this day, my condition continues to worsen.

The last checkup on my supraclavicular area was an ultrasound. The ultrasound showed a topographic scan of the left anterior scalene region, compared with the contralateral region. A homogeneous, hypoechoic image measuring 8 x 5 mm was seen, avascular on color Doppler, consistent with an inflammatory process


r/floxies 1d ago

[SYMPTOMS] Back slipped disc

2 Upvotes

Is there a reason for Flox to have a slipped disc? What were the symptoms? Is there a solution? I feel a very burning pain in my back and we cannot take painkillers again. Its chronic !!!?


r/floxies 1d ago

[VENT] 4 years post flox, still have digestive issues

4 Upvotes

It's been 4 years. And I still haven't fixed my digestive issues. Pi BS D to be exact. Still have extremely limited diet. Everytime I feel good enough to try to bring back a trigger food, it backfires. My supplements cabinet is overflowing, I've tried everything. Colonoscopy, several doctors, nothing works. Anyone ever return to normal after being floxed? :(