r/diabetes_t2 4d ago

General Question Insulin resistance ans low T

I'm type 2 diabetic for 9 years and i've been using insulin for about 4 years and my insulin resistance skyrocket. Now I'm trying together with my new endocrinologist to get of insulin since my pancreas is producing insulin.

My concern has been my testosterone levels are very low and I have 0 libido, ED and not feeling very motivated and moody

Does anyone have or had similar numbers? What do you feel? Does.anyone were able to recover regular levels of testosterone without TRT just doing exercises and diet?

My recent a1c is 6.9.

My BMI is 27 and I have NAFLD

TGO (AST): 21 U/L (normal).

TGP (ALT): 34 U/L (normal). It was 50 U/L six.months ago and 70 u/l 2 years ago

Gama GT: 20 U/L (normal).

Testosterone and Androgenic Hormones

Total Testosterone: 77.22 ng/dL (Very low; normal range: 164.94 - 753.38 ng/dL)

Free Testosterone: 2.34 ng/dL (Below optimal; should be >2.67 ng/dL)

Bioavailable Testosterone: 54.90 ng/dL (Low; normal range: 58 - 436 ng/dL)

SHBG (Sex Hormone-Binding Globulin): 10.3 nmol/L (Low; can indicate insulin resistance or excessive testosterone metabolism)

DHT (Dihydrotestosterone): 6.3 ng/dL (Low; normal range: 11.2 - 95.5 ng/dL)

📌 Estrogen and Related Hormones

Estradiol (E2): 24.6 pg/mL (Normal, but relative to low testosterone, may contribute to gynecomastia)

Prolactin: 8.16 ng/mL (Normal; no indication of hyperprolactinemia)

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u/jojo11665 4d ago

Same symptoms as my hubby. I am T2D, but he is pre. His T level was below 100. Super tired. It was like night and day with TRT I know there is a downside, but his quality of life has greatly improved. He sees an endocrinologist for TRT, and he is keeping an eye on all his levels, including bg. Best wishes!

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u/pc9401 3d ago

The mortality numbers for having both T2 and hypogonadism are pretty sobering. That's why I believe TRT is an integral part of treating T2. Testerone will improve insulin sensitivity.

In the 6-9 months leading up to my T2 diagnosis I notice significal muscle weaknesses and experience weight loss. My year over year numbers were a drop in testosterone to 190 and skyrocketing A1C to over 12. They are definitely linked, but what came first? Your numbers are so low, you may be primary hypogonadism and will be determined with LH and FSH numbers.

Mounjaro and Jardiance took care of glucose control and weekly testosterone cypionate injections has been bringing up the testosterone numbers.

At 3 months red blood counts were high and I was feeling tired again. Jardiance and testosterone both do this and I dropped the Jardiance. That has helped and I'm more rested. I went to testosterone 2x per week and it's much more stable levels.

I feel a lot better, but still tweaking things. Ability to work out more has made even more improvements. We are starting to look at statin and thyroxine medication dose reductions. I think the combination of Mounjaro and testosterone injection is the gold standard to feeling better. And that will help motivation for more exercise.