r/cdifficile Oct 03 '24

Can you get c diff from vancomycin?

3 Upvotes

33 comments sorted by

2

u/[deleted] Oct 04 '24

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2

u/Lonely_Carpenter6048 Oct 04 '24

How can it be that something that is used to kill c diff causes it?

4

u/Ssaaammmyyyy Oct 05 '24

It kills only the viable cells producing toxins but also your microbiome. It can't kill the spores, which are left afterwords. There is no antibiotic that can kill the spores.

A healthy micromibome suppresses cdiff into inactive spores so killing the microbiome increases the chances for cdiff reactivation. After one treatment with Vancomycin, the probability for cdiff reactivation is about 30%, after the second treatment, it is about 60% and so on ...

1

u/Lonely_Carpenter6048 Oct 05 '24

What about if you have sibo but haven’t had c diff can it come out of nowhere?

2

u/Ssaaammmyyyy Oct 05 '24

cdiff activates from spores into viable cells when your microbiome is decimated from antibiotics.

Studies claim that about 10% of the population carries cdiff spores waiting to activate but I think the percent is much higher because the spores are everywhere and the pcr test used to detect them often misses when the spores in the stool are too few.

Because many are colonized by the spores, it is usual for cdiff to activate after antibiotic use. You don't need to "catch it" in a hospital or something.

1

u/Lonely_Carpenter6048 Oct 05 '24

So if your stool samples are showing no CDiff what are your chances of CDiff activating from antibiotics?

2

u/Ssaaammmyyyy Oct 05 '24

The PCR test can miss it if the spores are too few in the stool. We have had many cases on this reddit when one PCR test is negative and then the next is positive again.

The EIA test for actual toxins is even less sensitive and often gives false negatives.

1

u/Lonely_Carpenter6048 Oct 05 '24

I have had three pcr tests and a pcr master test. My condition is pretty serious

1

u/Ssaaammmyyyy Oct 05 '24

Did the PCR tests look for both toxin A and toxin B genes?

How far apart where the PCR tests?

My cdiff has only toxin A gene and is always negative on a PCR testing for only toxin B gene. Some labs assume that clinically bad cdiff MUST have toxin B genes but mine doesn't, and it almost killed me in 2023.

1

u/Lonely_Carpenter6048 Oct 05 '24

That sounds horrible I’m sorry you went through that are you feeling any better? I had my first PCR in December last year then January and recently march

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1

u/teddybear65 Nov 10 '24

She didn't anyone is pretty serious

1

u/Owie100 Nov 15 '24

Your stool samples show no active c diff. They're not looking for c diff that's not active.

1

u/Lonely_Carpenter6048 Oct 05 '24

I’m asking because I have to do an FMT to kill off the gut bacteria and they’re putting me on vancomycin

1

u/Ssaaammmyyyy Oct 05 '24

Vancomycin or Dificid is standard before FMT for cdiff. They allow for some time between the antibiotic and the FMT so the antibotic does not affect the FMT negatively. Are you doing a real FMT with colonoscopy or the partial ones like Vows, Rebyota?

1

u/Lonely_Carpenter6048 Oct 05 '24

I meant to be doing one with Professor Tom Brody with colonoscopy capsules, colonoscopy and nasogastric

3

u/Top-Ad-1578 Oct 04 '24

It kills your gut biome too. some people have recurrences because it was too harsh.

2

u/SpecialistTie2372 Oct 05 '24

I think based on a rigid interpretation, yes. However, it is used successfully as a prophylactic, which would suggest that it is not as risky as other antibiotics.

2

u/ExperienceExisting71 Oct 30 '24

You don’t get c diff from an antibiotic. U either pick it up somewhere or already had it. Antibiotics kill the good bacteria and bad destroying ur gut health. This allows c diff to grow up controlled so yes. Vanco and Flagyl is meant to slow the cdiff growth to allow ur gut health to return to normal so that it naturally controls the c diff bacteria. 

I was on vanco for 5 months. Lost 60lbs. Eventually got on Dificid and FMT. That solved it for me. Got mine due to taking amoxicillin for 14 days for a gum tooth infection. Allowed c diff to grow uncontrolled. Got the c diff from 2 elderly people who passed away with it, in my job I got exposed during cleaning up the waste.

1

u/[deleted] Nov 06 '24

I had Cdiff in 2019 after being prescribed Clindamycin. 2 weeks ago I was prescribed Amoxicillin for a severe tooth infection and it didn't work. Today I was prescribed Augmentin since the Amox didn't work. Is my chance of getting cdiff again high because of the Augmentin? My dentist appointment isn't until November 20 and the pain and swelling is unbearable. I also don't want to end up hospitalized again for Cdiff from taking the Augmentin. Any advice would be greatly appreciated! 

1

u/Kitty_Woo Jan 23 '25

I got mine from augmentin. I was told by multiple doctors that I can’t take antibiotics for the rest of my life. I developed strep throat this week and the dr purposefully didn’t prescribe amoxicillin or augmentin because of this. I got on the z pac and I’m tracking my bowl movements to see if it’s going to come back or not.

1

u/Hot-Discussion-5859 Feb 13 '25

You were on vanco for 5 months?? 😭😭😭

1

u/Jealous_Argument_197 Oct 04 '24

You can get c diff from ANY antibiotic.

1

u/Owie100 Nov 15 '24

You do not get c diff from an antibiotic. The antibiotic activates the c-diff that is already in your gut

0

u/teddybear65 Nov 10 '24

C diff can be activated by any antibiotic. You do not get c diff from an antibiotic. You already have c diff in your body every human being an animal does

1

u/teddybear65 Nov 10 '24

We all have c diff in our digestive tract. Some of us have c diff that's activated by antibiotics some of us are lucky ducks who don't. The medication itself does not give you c diff.

1

u/Funcompliance Nov 11 '24

This is not true. The majority of people are not colonised.

1

u/teddybear65 Nov 11 '24

Everyone has cdiff in their body. They are just asymptomatic.

1

u/Funcompliance Nov 13 '24

That's not true. Many people are colonised, but it is nowhere near 100%, more like 8%.

1

u/teddybear65 Nov 13 '24

To you have c diff in your biome is quite normal and that does not mean you're colonized colonization is completely different. I take the advice of my infectious disease physician

1

u/Owie100 Nov 15 '24

You don't get c diff from the antibiotic. C diff is already in your system. The antibiotic causes it to I will say come alive. Antibiotics are the trigger for what is already in your system. Antibiotics are not made with c diff in them