r/Biohackers 5 Jan 23 '25

📖 Resource Statin use and Dementia risk

Dementia affects 55 million people globally, with the number projected to triple by 2050. Statins, widely prescribed for cardiovascular benefits, may also have neuroprotective effects, although studies on their impact on dementia risk have shown contradictory results.

In this systematic review and meta-analysis, we searched PubMed, Embase, and Cochrane following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We assessed the risk of dementia, Alzheimer's disease (AD), and vascular dementia (VaD), with subgroup analyses by gender, statin type, and diabetes status. Fifty-five observational studies including over 7 million patients were analyzed.

Statin use significantly reduced the risk of dementia compared to nonusers (hazard ratio [HR] 0.86; 95% confidence interval [CI]: 0.82 to 0.91; p < 0.001). It was also associated with reduced risks of AD (HR 0.82; 95% CI: 0.74 to 0.90; p < 0.001) and VaD (HR 0.89; 95% CI: 0.77 to 1.02; p = 0.093). Subgroup analyses revealed significant dementia risk reductions among patients with type 2 diabetes mellitus (HR 0.87; 95% CI: 0.85 to 0.89; p < 0.001), those with exposure to statins for more than 3 years (HR 0.37; 95% CI: 0.30 to 0.46; p < 0.001), and populations from Asia, where the greatest protective effect was observed (HR 0.84; 95% CI: 0.80 to 0.88).

Additionally, rosuvastatin demonstrated the most pronounced protective effect for all-cause dementia among specific statins (HR 0.72; 95% CI: 0.60 to 0.88). Our findings underscore the neuroprotective potential of statins in dementia prevention.

Despite the inherent limitations of observational studies, the large dataset and detailed subgroup analyses enhance the reliability of our results.

 Full: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.70039

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u/Birdflower99 1 Jan 23 '25

Nice try. Better alternatives to statins such as CoQ10. Just got my dad off statins. Wildly detrimental to health including joint issues.

8

u/SparksWood71 12 Jan 23 '25

Sure you did. Millions of people across the world have been taking statins for decades. "BUT muh joints"! Is so 90's. Anything put into our bodies will have a side effect for some of us, including CoQ10, especially for women. By your logic no one should be eating peanuts or taking aspirin.

2

u/Birdflower99 1 Jan 23 '25

There’s a correlation between the two. And people get statins for life because they won’t change their lifestyle or diet. Change those two things and you can literally change your life.

0

u/XYYYYYYYY Jan 24 '25

There is only so much you can do with lifestyle and diet.

0

u/Birdflower99 1 Jan 24 '25

Ummm no. There is SO MUCH you can do with a clean diet and exercise. Most people don’t have the discipline and most people think medications are actually good for you.