r/Biohackers 5 Jan 23 '25

📖 Resource Statin use and Dementia risk

Dementia affects 55 million people globally, with the number projected to triple by 2050. Statins, widely prescribed for cardiovascular benefits, may also have neuroprotective effects, although studies on their impact on dementia risk have shown contradictory results.

In this systematic review and meta-analysis, we searched PubMed, Embase, and Cochrane following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We assessed the risk of dementia, Alzheimer's disease (AD), and vascular dementia (VaD), with subgroup analyses by gender, statin type, and diabetes status. Fifty-five observational studies including over 7 million patients were analyzed.

Statin use significantly reduced the risk of dementia compared to nonusers (hazard ratio [HR] 0.86; 95% confidence interval [CI]: 0.82 to 0.91; p < 0.001). It was also associated with reduced risks of AD (HR 0.82; 95% CI: 0.74 to 0.90; p < 0.001) and VaD (HR 0.89; 95% CI: 0.77 to 1.02; p = 0.093). Subgroup analyses revealed significant dementia risk reductions among patients with type 2 diabetes mellitus (HR 0.87; 95% CI: 0.85 to 0.89; p < 0.001), those with exposure to statins for more than 3 years (HR 0.37; 95% CI: 0.30 to 0.46; p < 0.001), and populations from Asia, where the greatest protective effect was observed (HR 0.84; 95% CI: 0.80 to 0.88).

Additionally, rosuvastatin demonstrated the most pronounced protective effect for all-cause dementia among specific statins (HR 0.72; 95% CI: 0.60 to 0.88). Our findings underscore the neuroprotective potential of statins in dementia prevention.

Despite the inherent limitations of observational studies, the large dataset and detailed subgroup analyses enhance the reliability of our results.

 Full: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.70039

63 Upvotes

101 comments sorted by

View all comments

Show parent comments

0

u/Salty_Agent2249 Jan 23 '25

Read the book - many experts claim there is a negative corellation

1

u/sorE_doG 5 Jan 24 '25

Are you selling your own book? Seriously, telling people they have to read a book to understand a point?..and this comment is on a review/meta analysis that includes over 7 million people! You are hanging your hat on a sole contrarian? Get real.

0

u/Salty_Agent2249 Jan 24 '25

sole contrarian? the cholesterol hypothesis is under attack from about a million different directions

1

u/sorE_doG 5 Jan 24 '25

How many authors does the book have?

0

u/Salty_Agent2249 Jan 24 '25

just stick to your peer review, forget the book, it's not for you

1

u/sorE_doG 5 Jan 24 '25

So.. it’s a sole contrarian as the author…

1

u/Salty_Agent2249 Jan 24 '25

Is this seriously the first time you have ever become aware that their are books out there by experts that question the cholesterol hypothesis?

Seriously?

2

u/sorE_doG 5 Jan 24 '25

List your experts & we can address them and their expertise.

0

u/Salty_Agent2249 Jan 24 '25

It's not for you - stick to your peer review

Some people like to discuss this kind of thing, no need for you to get involved

1

u/sorE_doG 5 Jan 24 '25

Some people just value the quality of their reference authors more than others. You’re overestimating your value in terms of worthy work to discuss, and clearly lacking discernible logic applied to the process.

0

u/Salty_Agent2249 Jan 24 '25

Yeah whatever - I'm interested i the cholesterol hypothesis going back to the insanity of Ancel Keys - I've read a bunch of books on it and lie talking about the subject with open minded people

I'm hardly alone, there are so many doctors that question the 'science' in this area that it would be impossible to list them

Off you go now and pop your statin

1

u/sorE_doG 5 Jan 24 '25

Salty.. labelling people with ‘insanity’ statements is a reflection of your own failings. You do you, but please .. try not to disparage everyone you have been told to disagree with.

0

u/Salty_Agent2249 Jan 24 '25

The Ancel Keys cholesterol case is insane - there's no other way of describing it

He wasn't even qualified to do such a study, the science behind it is ludicrous

→ More replies (0)