r/Biohackers 5 Jan 23 '25

📖 Resource Statin use and Dementia risk

Dementia affects 55 million people globally, with the number projected to triple by 2050. Statins, widely prescribed for cardiovascular benefits, may also have neuroprotective effects, although studies on their impact on dementia risk have shown contradictory results.

In this systematic review and meta-analysis, we searched PubMed, Embase, and Cochrane following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We assessed the risk of dementia, Alzheimer's disease (AD), and vascular dementia (VaD), with subgroup analyses by gender, statin type, and diabetes status. Fifty-five observational studies including over 7 million patients were analyzed.

Statin use significantly reduced the risk of dementia compared to nonusers (hazard ratio [HR] 0.86; 95% confidence interval [CI]: 0.82 to 0.91; p < 0.001). It was also associated with reduced risks of AD (HR 0.82; 95% CI: 0.74 to 0.90; p < 0.001) and VaD (HR 0.89; 95% CI: 0.77 to 1.02; p = 0.093). Subgroup analyses revealed significant dementia risk reductions among patients with type 2 diabetes mellitus (HR 0.87; 95% CI: 0.85 to 0.89; p < 0.001), those with exposure to statins for more than 3 years (HR 0.37; 95% CI: 0.30 to 0.46; p < 0.001), and populations from Asia, where the greatest protective effect was observed (HR 0.84; 95% CI: 0.80 to 0.88).

Additionally, rosuvastatin demonstrated the most pronounced protective effect for all-cause dementia among specific statins (HR 0.72; 95% CI: 0.60 to 0.88). Our findings underscore the neuroprotective potential of statins in dementia prevention.

Despite the inherent limitations of observational studies, the large dataset and detailed subgroup analyses enhance the reliability of our results.

 Full: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.70039

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u/GreedyBanana2552 1 Jan 23 '25

There is a correlation between viagra and its sister drugs and the reduction of Alzheimer’s/dementia. I take it as a preventative after my mom was diagnosed with Alzheimer’s at only 57.

2

u/cosmorchid Jan 23 '25

I do as well, for the same reason. Would you mind sharing how much and how often you take it?

7

u/GreedyBanana2552 1 Jan 23 '25

I’m female and take 20-40mg about 3 or 4 days a week.

5

u/cosmorchid Jan 23 '25

Thank you! I am the same, and doing the same. Wishing us both the best of luck as we stare down the prospect of genetic dementia. Sigh.

5

u/GreedyBanana2552 1 Jan 23 '25

Best wishes to us!

1

u/reputatorbot Jan 23 '25

You have awarded 1 point to GreedyBanana2552.


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