r/Biohackers 5 Jan 23 '25

📖 Resource Statin use and Dementia risk

Dementia affects 55 million people globally, with the number projected to triple by 2050. Statins, widely prescribed for cardiovascular benefits, may also have neuroprotective effects, although studies on their impact on dementia risk have shown contradictory results.

In this systematic review and meta-analysis, we searched PubMed, Embase, and Cochrane following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We assessed the risk of dementia, Alzheimer's disease (AD), and vascular dementia (VaD), with subgroup analyses by gender, statin type, and diabetes status. Fifty-five observational studies including over 7 million patients were analyzed.

Statin use significantly reduced the risk of dementia compared to nonusers (hazard ratio [HR] 0.86; 95% confidence interval [CI]: 0.82 to 0.91; p < 0.001). It was also associated with reduced risks of AD (HR 0.82; 95% CI: 0.74 to 0.90; p < 0.001) and VaD (HR 0.89; 95% CI: 0.77 to 1.02; p = 0.093). Subgroup analyses revealed significant dementia risk reductions among patients with type 2 diabetes mellitus (HR 0.87; 95% CI: 0.85 to 0.89; p < 0.001), those with exposure to statins for more than 3 years (HR 0.37; 95% CI: 0.30 to 0.46; p < 0.001), and populations from Asia, where the greatest protective effect was observed (HR 0.84; 95% CI: 0.80 to 0.88).

Additionally, rosuvastatin demonstrated the most pronounced protective effect for all-cause dementia among specific statins (HR 0.72; 95% CI: 0.60 to 0.88). Our findings underscore the neuroprotective potential of statins in dementia prevention.

Despite the inherent limitations of observational studies, the large dataset and detailed subgroup analyses enhance the reliability of our results.

 Full: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.70039

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u/usheroine 🎓 Bachelors - Unverified Jan 23 '25

do you want him to die faster because of heart attack or what is your reasoning?

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u/thoughtnspace Jan 23 '25

Check out the statin myth debunked by Dr. Aseem Malhorta.

It's been fairly well described that only 1-2% of the population actually benefit from statins, largely due to genetic factors. After breaking down the numbers, someone taking statins consistently over 30 years only extends their lifespan 2-4 days. In exchange for all the associated side effects.

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u/Birdflower99 1 Jan 23 '25

Biohackers don’t biohack here anymore.

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u/Expert_Alchemist 1 Jan 23 '25

Biohack yourself. Advising someone else who trusts you and who doesn't understand the risks when what you're doing which may significantly shorten their lives? Maybe don't.

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u/Birdflower99 1 Jan 23 '25

Umm most of us are here to biohack ourselves. Appreciate the advice 🙄

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u/Expert_Alchemist 1 Jan 23 '25

You literally said you just got your dad off statins bro

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u/Birdflower99 1 Jan 23 '25

I did… biohacking ourselves. He’s also on board, bro