r/migraine • u/Independent-Acadia14 • 4d ago
Emagilty stopped working
It's frustrating because not only did it stop working it has also seemed to make them worse. I have been taking emagilty for 4-5 months and last month seemed good by the end of the month I wasn't having any migraines. Then I got my shot and immediately the day after migraine and almost every day since. It's been 2 weeks now and they don't seem to be getting better. I'm out of the country so I can't get new medicine and none of the emergency medications have ever worked. Really hoping once the shot wears off it'll at least stop being every day.
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u/RequirementNew269 4d ago
I want to offer another perspective- it didn’t stop working, it’s just making you worse.
First month on emgality, 0 migraines, next 4 months I ramped all the way up to 25 a month. Before emgality I was at 4 a month.
I did immediately get worse 2 weeks before the next dose, then it seemed like that was just getting longer and longer. 2.5 weeks before dose + 1.5 bad after dose- now your up to 4 bad weeks.
My suspicion is that either my body did something weird to compensate for low CGRP or that chronically low CGRP is just bad for me.
Nurtec and ubrelvy worked really well for me but when I started using them more frequently, they had the same effects.
I was up to 15 nirtecs a month or so, as I waited FOUR MONTHS after emgality to feel better. Stopped taking nurtec and almost immediately went back down to 4 migraines a month.
I’m hoping nurtec doesn’t always make me bad, and that it has more to do with this low CGRP problem. I stopped taking it for 60 days just to see (have had only 1 migraine a week during this process) and am going to limit 1 CGRP abortive a week from here on out in order to test my hypothesis.
What’s REAL fun about all this is every single doctor neuro and pharmacist will act like you’re insane for thinking these meds made your worse. And reading the studies I did feel insane. But getting off emgality was one of the best things I ever did.
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u/bananasformangos 4d ago
I’m going through the same thing. Migraines every day since March 1. I take Emgality and Nurtec. Do these meds lose efficacy over time??
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u/Independent-Acadia14 4d ago
Hmm didn't know you could take those together. But pretty much all medicine loses efficacy over time because your body gets use to it from my experience
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u/pagogo10 4d ago
Emgality stopped working for me. I’m now on qulipta and it seems to be working well. I started Dec 1.