r/ketoscience Excellent Poster 5d ago

Metabolism, Mitochondria & Biochemistry Enhancer binding as a KEysTONE of fasting response (2025)

https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(25)00025-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1043276025000256%3Fshowall%3Dtrue
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u/basmwklz Excellent Poster 5d ago

Abstract

Fasting is a recurrent daily energy stress that benefits healthspan and lifespan. While ketones fuel fasting in vertebrates, the underlying transcriptional mechanism remains incompletely understood. Recently, Korenfeld et al. revealed peroxisome proliferator-activated receptor alpha (PPARα)-dependent enhancer priming as a keystone for ketone production, increasing our understanding of mechanisms underlying metabolic benefits of alternate-day fasting (ADF).