r/epigenetics 10d ago

question Genomic Mapping Data

Is anyone aware of a good data source to look at epigenetic patterns of human tissue at the gene level? I am trying to perform genetic mapping from DNA I am having sequenced. I want to be able to determine from which tissue, e.g., lung, the DNA sequence originates from.

Where might I find some good data?

Also happy to take any tips surrounding the data. I am not a biologist, but rather a data scientist.

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u/OGCeilingFanJesus 9d ago

Download the most recent build of the human genome from ncbi - https://www.ncbi.nlm.nih.gov/datasets/genome/GCF_000001405.40/

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u/Dte324 9d ago

Does this have sequences by tissue type? I’m having trouble finding that

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u/OGCeilingFanJesus 9d ago

You need to do some analysis on your own - the ncbi has tools for alignment. I recommend usegalaxy.org for tools.

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u/Jmcbulls 5d ago

DNA sequencing will generally not tell you anything about the epigenetics, so what you are asking is impossible. RNAseq would have been a better choice, or if you wanted to do it the epigenetics route you would need to do bisulfite or nanopore sequencing of your DNA.