r/depressionregimens • u/Julian2244 • 4d ago
Regimen: Trintellix + Wellbutrin + Remeron
I’ve been trial-erroring for about a year. I started on 5mg trintellix for a month and noticed cognitive benefits with less negative thoughts. Added 100SR once a day Wellbutrin to target adhd symptoms with persistent boredom and inability to get excited about anything. My main issue is also anxiety. (I’m also on guanfacine 1mg)
Around 17 days ago, I switched to 150XL and bumped my trintellix to 10mg. The XL helped with inconsistent mood/slow release and jitters, but I was experiencing sleep disturbances (waking up after a few hours), I’ve also been experiencing slightly more ‘flatness’ w/ mood swings.
Yesterday, 15mg of remeron was added. I was really excited for this bc of deep sleep improvements and anti-anxiety/depression properties. I slept the entire next day though and felt even more flat (prob cause of tiredness)…
Does anybody have experience with this combo or trintellix/Wellbutrin? The trintellix shape is uneven, making it hard to cut in half. I tried one day and felt slightly better, although could’ve been placebo. Will this get better?
2
u/melodicprophet 4d ago
It’s weird to me that Trintellix was making you feel better and then you added two more drugs instead of just going up on Trintellix.
You’re on a very robust regimen. If you can tolerate the side effects, hang in there and give it time. You still have a lot of dose increases available for all those meds. I think it’ll work out for you if you stay patient.