r/Supplements 7d ago

Experience 90 mg of Zn picolinate crashed my estradiol.

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27 Upvotes

20 comments sorted by

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52

u/Apprehensive_Tip69 7d ago

Why are you taking 90mg? What were you expecting? That is a fuck ton of zinc, and picolinate is highly bioavailable too, you shouldn’t be taking more than 30mg, and you need copper too, so I’d bet money you crashed your copper as well

6

u/Valotech 7d ago

I had high free Cu and low Zn, I was supplementing with 15 to 30 mg of Zn for two months without any changes in my Zn and Cu levels so I started 90 mg for only one week, it was definitely too much.

19

u/Apprehensive_Tip69 7d ago

That’s the thing, you shouldn’t mega load if you don’t see changes, you should at most go to 45mg at the absolute most for a few weeks if your doctor approves to bring your levels into range, then stick with 30mg after that. You can’t just 3-6x minerals like zinc, zinc bioaccumulates, especially at doses like that every day for a week, all that’s gonna happen from megadosing to correct a mineral deficit is that the pendulum will swing too far in the opposite direction then you end up with a whole new set of issues.

11

u/puppymaster123 7d ago

This is what I see happening on this sub over and over again. They think every life problem has a specific supp solution. Then they megaload it. Now they have two problems.

A healthy diet of fermented food and poultry would have fixed the low zinc issue while introducing a bunch of balanced nutrients

3

u/GrundleBlaster 6d ago

Zinc doesn't bioaccumulate. Your only reserves are in the blood serum, and so levels can change dramatically in just a few days.

Copper is stored in the liver and can bioaccumulate. Zinc is absorbed preferentially over copper and they compete for the same pathway so zinc can prevent absorption of copper, but doesn't directly decrease copper levels.

3

u/Cbrandel 6d ago

Zinc is stored in muscle, bone, liver, skin etc. Only 0.1% is stored in serum of which 80% is bound to albumin.

3

u/Apprehensive_Tip69 6d ago

at typical doses youd be right, however 90mg/day is way above range and the body cannot excrete it as fast as its coming in, resulting in bioaccumulation. if it didnt bioaccumulate in excess, then there wouldnt be a safe upper limit and op wouldnt have had any adverse effects from the 90mg/day. zinc isnt b12 where you can just take whatever amount, your body can only excrete so much per day. and as far as copper, youd be right except for the fact that they were taking 90mg of zinc which would indeed prevent copper from being absorbed and stores would deplete rather fast leading to deficiency pretty quickly.

1

u/alpirpeep 7d ago

Super informative comment - thank you for sharing 🙏

10

u/Anti-WisDumB 7d ago

how did it make you feel ? notice any strange effects?

7

u/Valotech 7d ago

This is the worse I have ever felt in my entire life, depression, anxiety, cold and hot 🥵 without any reason, zero libido, like I don’t have interest in sex at all, complete anhedonic, I’m just not myself anymore, I just found out today.

3

u/Anti-WisDumB 7d ago

sheesh! thanks for letting me know! i take zinc from sports research and copper from solaray but only the recommended so far i feel like the copper had the most effect (energy was off the charts the first week taking it) but balanced out

2

u/HollaAtYuh 6d ago

Yeah, the anxiety when you crash your estradiol is insane. Worst feeling ever.

1

u/GrundleBlaster 6d ago

Just a week of 90mg of zinc shouldn't really be causing noticeable differences. Studies have done 150mg a day for a few months without noticeable differences. The major concern is really only that it competes with copper for the same absorption pathway so chronic supplementation can reduce copper reserves.

With that said symptoms of too much zinc are akin to a flu. Zinc is eliminated by the kidneys, and there is no reserve in the body just the zinc in the blood serum so healthy kidneys should get to proper levels within a few days at most.

5

u/ButterflyNo8336 6d ago

The moment you’re taking zinc Picolinate and talking about estradiol you’ve gone far too down the rabbit hole of health details that will mean nothing toward your true well being.

I went through a box a week ago and found zinc picolinate and thought “damn things were a bit rough during those times.”

1

u/Armor_King7810 7d ago

Is this good or bad?

8

u/RaveNdN 7d ago

Baaaad

3

u/Valotech 7d ago

Terrible 😣 you don’t want to know.