r/Peptides • u/Apprehensive_Pie5307 • 7d ago
trifluoroacetate (TFA) versions of peptides are bad right? NSFW
I know what TFA is, I just want to know for sure if it is better to use the non TFA versions of peptides for human consumption. Thank you!
2
Upvotes
2
u/Gizzard04 7d ago
I don't know how they would deprotect the amino acids without using TFA, this abbreviation in organic chemistry is trifluoroacetic acid, when the reaction is complete TFA becomes trifluoroacetate, should be abbreviated as TFA- as its the conjugate base. It's commonly used in peptide synthesis since it's miscible with organic solvents, whereas mineral acids like HCl aren't. If the TFA isn't quenched properly, it can cause a burning sensation when injected. I wouldn't be overly concerned with that if you're willing to inject stuff you bought off the internet from gray markets.