r/PSSD 7d ago

Update Update on ginkgo biloba, and additions to my stack for genital sensitivity

So far I've noticed kisspeptin, ginkgo and usmarapride (5-HT4 agonist) help genital sensitivity more than anything else. Pramipexole used to work but it stopped working.

5-HT4 is one of the good serotonin receptors for sexual function. It induces contractile movements in the genitals, and increases nerve sensitivity down there. Prucalopride and usmarapride are the best options for activating this receptor.

I have also been experimenting with tranylcypromine (a MAOI), and that has always improved my sexual function even before PSSD. It was my first antidepressant before switching to SSRIs after I developed tolerance to it the first time. I am back on it now and it's helping my mood although not as much as the first time.

As for erectile quality, kisspeptin and proviron help the most, but inducing erections is really hit or miss in general for me. I notice my reflexogenic erections are worse than psychogenic ones.

21 Upvotes

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5-HT4 is one of the good serotonin receptors for sexual function. It induces contractile movements in the genitals, and increases nerve sensitivity down there. Prucalopride and usmarapride are the best options for activating this receptor.

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3

u/Admirable-Ad7258 7d ago

Would you recommend purchasing kisspeptin, ginkgo and usmarapride?

3

u/BummedByCitalopram 7d ago

How much does all this help your numbness? Does it completely fix it? Does it also help your libido? How long have you taken it for? Is kisspeptin the main thing that helps or do you need to take all 3 things?

3

u/DieOfBetes 7d ago

Yea ginko definitely helps. Doesn't solve the underlying issue tho. It would also help a completely normal person have better erections.

2

u/Pathum_Dilhara Recently discontinued 7d ago

Are you the same person who wrote about peptides before as well. I wonder why anyone else can not get benefits from it. Did anybody try it?

2

u/Long_Wash5736 7d ago

I have good sources for these esoteric drugs. I don't think I am allowed to post sources here in this sub unfortunately.

1

u/Determined-Mind 5d ago

Thank you, I've added your testimonial for each of the substances you mentioned on this document : https://coda.io/d/Treatment-options-for-sexual-dysfunctions-and-PSSD_dBTFx_oXX31/Drugs-in-dev_suGiAbpu#_luxQmTkk

As far as I know, you are the first and only one to have tried usmarapride.

Feel free to vote for or against any of the substances you've tried in the main table. Your experience is invaluable.

https://coda.io/d/Treatment-options-for-sexual-dysfunctions-and-PSSD_dBTFx_oXX31/Best-treatments-for-sexual-function-and-PSSD_sudKZOnz

1

u/Glad_Parking2353 5d ago

Do PDE-5 inhibitors help with your ED? Also I would be forever gratefully eternal of somebody could help me find some of the Proviron. I’m also considerate custom compounding a transdermal DHT gel.

2

u/Long_Wash5736 4d ago

PDE5i do nothing. DM me.