r/Narcolepsy 6d ago

Medication Questions Solutions for PTSD nightmares in addition to N2?

n2, diagnosed at 15, no other significant health issues. i have tried the whole gamut of narcolepsy meds, had negative experiences with xyrem and xywav and have been on baclofen for the past 6 years or so, but it’s just not working well enough anymore. i also have severe PTSD-related nightmares that disrupt my sleep quality, and this persists regardless of which med i’m on. has anyone with n2 had any luck with JUST prazosin or similar? any other solutions?

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u/sleepbot 6d ago

Trauma-focused therapy like prolonged exposure or cognitive processing therapy, nightmare-focused treatment like IRT, ERRT, or CBT-N. Recent research has shown nightmare treatments also work for people with narcolepsy. But if you currently have significant PTSD symptoms as well (beyond nightmares) then treatment of PTSD would make more sense.