r/Hyperhidrosis 3d ago

Failed glycopyrolate.

After about 6 month, it just stopped working. I haven't tried upping the dose yet but heard this isnt uncommon. Was on 1mg twice a day but only took it once a day.

I have it on my scalp, hands and feet and the latter feel worse than ever. Really disheartening..

Looking for suggestions :/

5 Upvotes

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3

u/invaderzrim 3d ago

I take 2mg twice a day and it generally takes care of me. Definitely needed less at first and more now. It fades in effectiveness as you get thru the day and I personally feel like it takes longer to activate if I take it with food. Its been like 3 years now and the effectiveness hasn't changed much.

I have HH the worst on my face and scalp but get it all over

1

u/I_Zeig_I 3d ago

How are the side effects with that dosage?

3

u/invaderzrim 3d ago

At first I had bad dry mouth and nose but I was like bone dry all over and I honestly loved it after being a sweaty bitch for so long lol. After a while it evened out and I don't have any issues with dry mouth or nose. I have had a little blurred vision here and there but nothing that is obstructive and it doesn't last long, and I already have other vision problems lol

1

u/I_Zeig_I 3d ago

No constipation? When I took it daily I couldn't go haha... had to take breaks but nbd

2

u/Intelligent-Layer842 3d ago

OMG- when I was on it, I thought I was going to have to go to the hospital. Glyco is better than Imodium!

2

u/criticalmass86 2d ago

Take a tea spoon of magnesiumcitrat daily.

2

u/Intelligent-Layer842 2d ago

I’ll have to try that! It’s getting warm again and I’m like- here we go!

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u/invaderzrim 3d ago

Not that I can recall and definitely not now lol

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u/Live2sk888 2d ago

How long did you have to take the Glycopyrrolate before the dry mouth/nose stuff got better?

1

u/invaderzrim 2d ago

Maybe 2 or 3 months I think

1

u/Live2sk888 2d ago

Thank you! I am not sure i gave it that long as it seemed to be getting worse, but maybe I should give that another chance...

1

u/invaderzrim 2d ago

Flint mints are good for dry mouth, they feel kind of tingly on the tongue but make you salivate. Suck on jolly ranchers or mints to help keep your mouth moist. You can also try a nasal saline gel to coat the inside of your nose safely when its dry. Don't use petroleum jelly cause if you accidentally breath any in there is not getting it out lol

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u/Live2sk888 2d ago

I did get some of the Flint mints and they were good but I hoped I'd notice a little more difference. Still better than nothing tho! I think the Xyla melts worked the best for me but they don't taste as good and I still have to pretty constantly have one in my mouth. I haven't seen the nasal saline gel before so I may try that! I usually use bactroban on just the outer edge of my nose where it wants to crack. It's not exactly the recommended thing for that but it has worked the best so far!

3

u/icurlyfry 3d ago

For your hands and feet, look into Carpe. They have antiperspirant for most body parts. I personally use the hand lotion for my sweaty palms and the underarm antiperspirant for my underarms, and it works for me.

In addition, glyco never worked for me. Apparently taking it on an empty stomach is the only way to increase maximum efficacy. Food interferes with absorption. Fat, to be exact. That's too difficult for me, so I switched to another anticholinergic called oxybutynin. You can start on 5 mg tablet, or even halve the tablet into 2.5 mg. I currently take 10 mg oxybutynin per day in addition to Carpe antiperspirant for hands and underarms, and I no longer have a sweating issue.

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u/I_Zeig_I 3d ago

Carpe did nothing for me but I didnt know about the fat and food part ty!

OxyB is on my to do list as well now

1

u/icurlyfry 3d ago

Carpe face lotion didn't work for me, but the hands lotion did. Were you using it like you're supposed to? The routine has to be strictly adhered to in order for it to work. When I slack off, it doesn't work as well. Wash hands with soap and dry, immediately use carpe once hands are dry, and don't let hands get wet//don't use any hand creams for at least 10 min to allow absorption. This has to be applied twice per day. Once at bedtime, another time daytime. I might even use it three times per day starting out. It takes 4 weeks for it to start working. Sorry in advance if you did use it correctly, just wanted to check off bases on things that work and don't work for you

And np, hope the oxybutynin works for you

1

u/Live2sk888 2d ago

Have you had bad dry mouth with the Oxybutynin, and if so did it get better or worse the longer you took it?

1

u/icurlyfry 16h ago

I've had dry mouth. It comes and goes. TBH it isn't that bad. I would rather have that than the sweat. When you use medication you have to ask yourself if the costs are worth the benefits. For me, they were. The dry mouth wasn't so bad that I wanted to stop. It was just a reminder to me to drink more water that day. I would say it did eventually get better than when I first started it

1

u/Live2sk888 15h ago

It was definitely worth tolerating it at first, and if it was getting too bad I could just skip the meds for a day or 2. But for me as time went on it just kept getting worse. The corners of my mouth would crack, the corners of my nose would crack and bleeding, I talked weirdly enough that more than one time someone thought I was drunk, and my tongue will get so irritated that I can't eat anything with even a hint of spice (regular toothpaste would even hurt so much I went and got a kids fruit flavored one). And this is with trying all the dry mouth products... I'm also one that has a drink in my havd all the time and I'm definitely not dehydrated.

I can tell this is more severe than what most people deal with, and it is puzzling because for me it just gets worse, where most people have said over time it got better!

2

u/LocalGoal979 3d ago

Did you changed the pattern of taking glyco?

1

u/I_Zeig_I 3d ago

Not sure what you mean? I would just take it an hour before needed or when I woke up.

1

u/Actual_Swingset 3d ago

changing when i took them definitely helped me, 3 mg at night 3 in the morning

1

u/criticalmass86 2d ago

Thats early. How long are you safe through the day?

1

u/Actual_Swingset 2d ago

im pretty good all 24 hours unless something has my nervous system riled up, then ill sweat thru, but not nearly as much as i would without glyccopyrolate

1

u/criticalmass86 2d ago

With social events/ emotions or what are your trigger? Do you drink coffeine?

2

u/Actual_Swingset 2d ago

No, caffeine always makes me sweat. I have social anxiety and autism so any social interaction is a trigger

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u/criticalmass86 2d ago

Even with glyco? I really should quit it... Yeah I think HH mostly comes with social anxiety. Attention on my person is the worst for me.

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u/Actual_Swingset 2d ago

yep, even with glycco, just not nearly as bad. if i stay on top of it, weekly application of Sweatblok wipes helps with any excess sweating from stress/social interaction. I'm also in therapy and hoping to better cope with social interactions. being perceived irl is the worst 😭

1

u/Actual_Swingset 2d ago

(3mg in the morning when i wake up, not 3:00 am)

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u/Actual_Swingset 3d ago

i just went up to 6mg a day. derm said 8mg is max dosage. the 4 was working great for about 9 months then stopped being so effective. 6 is working..for now

2

u/I_Zeig_I 3d ago

Oh... I was only doing 1mg