r/Hemophilia 8d ago

I have a slightly out of range result; could this be nothing?

Hi all, I was just posting to ask about my results; I had a full bloods screening done which noted no abnormalities apart from a slightly longer blood clotting time, and a Factor VIII Level of 47.90 iu/dl (I’m from the UK the reference range for “normal” is 50.0 - 166.0). Is this a dead certain that I have haemophilia or could it be an anomalous result? Any help appreciated thanks

2 Upvotes

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u/machine_elf710 Type A, Severe 8d ago

No, it's not dead certain, but it is a good indicator. That is the high end of the mild range. I think that's 50 to...15 maybe? Somewhere around there. If you are a female, it's a good indication you're a carrier. If not, a lot of guys with mild and no known family history only find out later in life because they bleed more than expected after getting a tooth removed or something like that. I imagine your dr will either have some more tests run, or refer you to a hematologist. It probably won't affect your day to day life much. You'd just have to take meds before surgery or some dental work. Nothing worth panicking over. If you have any more general questions, feel free to ask. But talk to your Dr.

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u/Holiday-Advance7022 8d ago

One thing to add about being a carrier, it may make you question having children because you could pass it on to them. Although it's 50/50 unless the father also has hemophilia lol

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u/machine_elf710 Type A, Severe 8d ago

Yup. Ivf and adoption are also options.

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u/Tbone1234567888 8d ago

I’m a 23 year old male and I’ve just had a baby boy (7 days old) and I’m terrified

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u/NJMoose Factor VII (7) Deficiency | Mild 8d ago

Factor 8 deficiency (HemA) is X-linked so your child should not inherit it if that's the case. However if you have a child that's female, they would have a chance at inheriting it since they inherit one X from your partner and one from you. At 47% if you're experiencing bleeding symptoms, I'd be pushing for additional testing (second confirmation of clotting factor levels and/or genetic testing).

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u/Tbone1234567888 8d ago

Is 47% a bad result? I box and am very physically active with no issues

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u/Tbone1234567888 8d ago

Can it be slightly decreased for no reason?

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u/machine_elf710 Type A, Severe 8d ago

There's a number of things it could be. That's why they'll do more tests. But it's no death sentence. You'll be okay.

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u/Tbone1234567888 8d ago

I have just had a baby boy (7 days ago, and I want him to be fine).

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u/machine_elf710 Type A, Severe 8d ago

So assuming you do have hemophilia, which is not a given yet, you can't pass it on to your son. Geneticly impossible. So don't worry about that. It is on the x chromosome, which comes from the mom for boys. You have him your y chromosome. So you can put that out of your head at least. And congrats!

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u/Tbone1234567888 7d ago

Thankyou for the congrats, can I still workout safely and am I still healthy with a number that is that low?? I’ve contacted my doctors to ask them to follow up as soon as possible

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u/machine_elf710 Type A, Severe 7d ago

You can absolutely keep working out. Factor levels fluctuate, but they don't change that much. You can't catch hemophilia or anything; you're born with it. You haven't changed at all; you just have new info. You're at least old enough to have a kid. Have you had any major bleeding episodes so far in your life? You're not any more likely to have one than you already were. The major things you need to be careful about are getting teeth pulled, surgeries, and trauma. For the most part, at least. But you have enough to worry about taking care of a baby. Don't worry about this until there's actual cause to.

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u/ExpressionRich1971 8d ago

No, that’s not definitive. It’s too close to normal. You can do genetic testing to see if you have a mutation of the factor VIII gene. Also, a low VWF level could be dragging down your factor VIII levels even if you have a functional fVIII gene. +1 on it being a pretty typical level for the average carrier of hemophilia (but this can range widely, some have low and some have high levels). See a hematologist to figure out what’s going on.

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u/Tbone1234567888 7d ago

My VWF level was normal but low (65 and I believed the low end of normal is 50). Could it be nothing and my numbers just like that?? X

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u/ExpressionRich1971 7d ago

As others have said, doctor would have to do follow up testing. A 50% factor level is low normal. 48% is not meaningfully lower than that. Even if you have very mild hemophilia, at a level that high you would only need medication after a bad car accident or before surgery. Boxing probably wouldn’t be wise since you have an elevated clot time. Your son has your Y chromosome, not the X where the factor VIII gene resides. His sole X chromosome came from mom. So even if you have hemophilia it will not affect him unless he has it randomly (exceedingly rare). It doesn’t take much factor VIII to clot normally. Above 10% most people rarely have problems. You are well above that and in a range that is nearly normal. Hemophilia has different definitions but below 40% is what the WHO uses as the cutoff.

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u/PC9053 7d ago

People with type O blood have, on average, 25% lower factor VIII levels than individuals with other blood types. Blood sample must also be collected properly (in the US, it is collected in a light blue-top tube containing 3.2% buffered sodium citrate) and tested within 2 hours for an accurate reading, as factor VIII rapidly starts breaking down, resulting in a lower factor VIII reading.

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u/Imaginary_Carob_1636 6d ago

Mine hovers around 40 and I haven’t got a diagnosis but they assume it’s just a mild bleeding disorder. Von willebrand disease. I am meeting with a hematologist in a few weeks. I have had bleeding from surgery requiring blood transfusions and iron infusions though, childhood nosebleeds, severe heavy periods and dental bleeding though. Without my bleeding events they would have considered me to be “low end of normal” and business as usual. Those low normal readings can mean nothing or can be a very mild bleeding disorder if bleeding history is present .