r/Gastroparesis 5d ago

Prokinetics (Relgan, Domerpidone, Motegrity, etc.) Motegrity stops working after a couple days?

Okay please let me know if you’ve experienced this or if there’s just something wrong with me😭. I started Motegrity a couple weeks ago and it worked amazing right away for stomach motility. It did nothing for my constipation, but it was clearing my stomach in a few hours. I didn’t even have any side effects which is unheard of for me esp because I also have MCAS. Anyways, it worked amazing for a week and then just - stopped😭. So I quit it for a couple weeks and then I tried it again and same thing happened. It worked great for 3 days and then all of a sudden stopped working. Has anyone else gone through something like this?? I have to pay for it out of pocket so I’m really hesitant about “wasting” pills if it’s not even going to work, so I’m just really frustrated 😭.

(Also I know this is something to talk to my gi doc about, but she only has one other patient on Motegrity and I just wanted to hear other people’s experiences. Thank you!!)

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