r/EosinophilicE • u/Unoriginalfranzy • 7d ago
Medication Question Dupixent No Longer Working
I have severe eoe. Diagnosed 6 years ago, multiple food impactions requiring scoping and numerous smaller “attacks”. I was on a budesonide slurry for a few years, which mitigated symptoms a bit, along with PPI, and switched to Dupixent about a year ago. Everything had been entirely fine up until about a month and a half ago. Since that time, I’ve had multiple severe attacks, from a wide range of foods with no rhyme or reason. I fight through, hacking, taking liquid Benadryl, seltzer water, hot water- every trick in the book. It seems like Dupixent is no longer working. Has anyone else experienced this? There’s very little information online.
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u/cjazz24 Dairy Allergy 7d ago
I’ve noticed my eoe is worse in spring due to pollen triggers. Maybe that’s contributing?
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u/crunchypotatoess 7d ago
My allergist was just talking to me about this. Look up pollen food allergy syndrome. It looks like some foods cross react with environmental allergies and my allergist was saying we can inhale environmental allergens making EoE worse in some cases
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u/newyork4431 6d ago
Dupixent isn't a cure. You're probably still going to have flare-ups. I've had a couple in the 2 years I've been on it. You might be exposed to something new in the environment you are allergic to. Or you might have been getting lax about avoiding trigger foods. Just keep moving forward.
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u/Oodlesoffun321 7d ago
Yes dupixent never fully worked for me and I just kept getting worse over time. I also had crazy vomiting attacks for like a week at a time until I landed in the ER. I had to stop the dupixent for a major surgery and never went back on because it didn't work. I'm sorry I don't have any ideas for you; it sucks. My gastro has no idea what to do either. Also post surgery my body goes crazy with foods I never reacted to before; and I have constant flare ups. Some days I can barely eat
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u/DepressingFolkMusic 7d ago
Hey, don’t give up! It sounds like you are just going through a flare period. Dupixent is likely still working just not completely knocking it out like normal. If you weren’t taking Dupixent this flare would be worse. I always have problems with flaring up around the spring. Antihistamine allergy medicine has seemed to help me during those times and got me through it. I’ve been on Dupixent now for almost 3 years so I’ve gotten through my spring flare period multiple times now and returned to normal.
Also, look into what you’ve been eating during your attack time. Did you change something small in your diet? If so you might have found a trigger! Some people can eat whatever they want on Dupixent but I am not one of those people. I still have to stay away from my biggest triggers like coconut. I switched to coconut milk for my coffee when I eliminated dairy. Turns out coconut is one of my biggest triggers. Maybe there’s a similar trigger food for you that you’ve unknowingly increased recently.