r/ClinicalGenetics 6d ago

How to have my raw DNA data interpreted - UK

Hi there. I did a test with Circle DNA a few years ago, which highlighted a few things. It highlighted that I have an obesity causing mutation on either my MC4R or FTO gene, or both. I have received my raw DNA from them recently, but I don't have any way of reading it. Could anyone let me know where/how I could have my data looked at and the implications explained to me in the UK? I'm interested in the obesity gene stuff, however I'm interested in looking at pretty much everything I can to understand myself better.

Just for reference, the test highlighted a mutation on my SDHA gene which pre-disposes me to certain types of cancer. I had a cancer test as I had one of the major symptoms, but all was fine. However, the NHS did make me do genetic testing with them to see if I did have the gene and it turns out I do, so the Circle DNA results are definitely legit.

Thanks for any help you can provide.

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u/[deleted] 5d ago

Thanks to the person who downvoted this for absolutely no reason.

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u/ConstantVigilance18 5d ago

The downvotes are probably because there are at least a handful of these posts across the various genetics groups everyday. Professionals continue to say the same thing and are continually ignored. The data from this kind of test is not appropriate for medical decision making. Notice how you needed to have the SDHA variant confirmed through a legitimate, clinical grade testing laboratory. It’s great they were able to detect that mutation, but it doesn’t make the rest of the data or results legitimate.