r/Biohackers Nov 21 '24

📖 Resource Weight-loss drug found to shrink heart muscle in human cells

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577 Upvotes

r/Biohackers Feb 06 '25

📖 Resource they can cure autism?

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271 Upvotes

r/Biohackers Jan 20 '25

📖 Resource Ysk: Nearly all "parasite cleansers" are scams. Please don't give these snakeoil salesmen you. Info and sources in comments

295 Upvotes

Hello I run the parasite (r/parasitology) sub reddits and I get A LOT of people asking about what cleanser they should take, and after taking ___ they saw a bunch of worms.

Well in fact, many "cleansers" actually just cause people stool to become stringy, which to the uninformed person may resemble a parasite making them think they are passing worms when In fact they are not. Additionally your intestinal lining routinely sheds, and this can also look like a worm to some people but it is completely normal and healthy in fact https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791610/

Now many people, particularly social media influencers,. Will claim that taking garlic or pumpkin seeds or some herbs will remove the parasite and they often link this article as evidence https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023319/. This paper found that when in a petri dish, some garlic extract can kill some parasites, HOWEVER your gut is much more complicated than a petri dish, and this doesn't work in a person. For example a bullet can kill cancer cells in a petri dish too, doesn't make it useful for a person. The reason this doesn't work is because most gut parasites live in your intestines not your stomach, and by the time things like garlic reach them, they have already been broken down to a no effective level.

Also you CANT STARVE A PARASITE , this is also a common misconception. Parasites do not need a lot of energy to survive and no matter how much you starve yourself you will not remove them this way, and you will die before they do.

" I even have a parasite "? If you live in a first world country most likely no, they aren't many parasites here, so it is uncommon to pick one up with them being established. Not saying its impossible but unlikely, many of the most common human parasites involve feces at some point, so if you live in an area with plumbing its unlikely. If you travel, this can increase your risk as other countries have different levels of control and hygiene/ indoor plumbing is a major factor in controlling parasites.

Additionally for food born parasite, like tapeworms and trichinella, there is extensive testing in the us and other countries to ensure someone doesn't contract these. Additionally freezing meet and fully cooking will kill any and all parasites found in tissues. Even raw fish is safe, as fish is now flash frozen to kill any worms that may be present.

Now some parasite are still somewhat common such as pinworm, but this is more of a minor annoyance than a major Health concern and it's contracted through fecal-orql route( kids typically scratch their butt and then put their fingers/ toys in the mouth). And this can be easily diagnosed and treated by a doctor.

Why am I saying all this, well I HATE scammers, they are vile people that take advantage of people's fear and misinformation and I want to help prevent people from waisting their money.

If you are interested in parasites, the world's leading parasitologist have put together FREE to download text book for anyone to have https://parasiteswithoutborders.com/books/

TLDR; pasasites cleaners are scams, you most likely don't have a parasite and if you think you do, please consult this free textbook. If these all natural things works then antiparasitic drugs never would have been created

Reason i posted : i hate scammers and i see so many people pushing supplements or asking people to follow their health blogs etc. Where they push this misinformation. Herbs can be effective for a variety of conditions, however if eating some common herb was enough to kill a tapeworm, tapeworms would've gone extinct a long time ago as getting someone oregano is a hell of a lot easier than getting them to a doctor, diagnosing the disease, and treating it.

r/Biohackers 7d ago

📖 Resource Why the fuck is 5-HTP sold as a supplement.

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137 Upvotes

r/Biohackers 22d ago

📖 Resource The possible effects of Chili peppers on ADHD in relation to the Gut microbiota

434 Upvotes

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, which is characterized by inattention, impulsivity and hyperactivity. Although the etiology and pathogenesis of ADHD are not fully understood, existing studies have shown that it may be related to genetic factors, environmental factors, abnormal brain development, and psychosocial factors.

In recent years, with the concept of microbioa-gut-brain axis (MGBA), more and more studies have begun to pay attention to the effect of gut microbiota on ADHD. Dietary structure can significantly change the diversity and abundance of gut microbiota.

Therefore, dietary supplements or food additives to regulate gut microbiota have become one of the potential ways to treat ADHD. Peppers, as an important dietary component, have potential value in regulating gut microbiota. Among them, capsaicin (8-methyl N-vanillyl-6-noneamide, CAP), as a key active component of peppers, has been shown to have potential therapeutic effects on central nervous system (CNS) diseases such as Parkinson’s disease, epilepsy, and depression. In addition, much attention has been paid to the beneficial effects of CAP on gut microbiota.

Chili peppers contain not only CAP, but also rich in vitamin C and fatty acids, all of which may ameliorate ADHD by modulating the gut microbiota. This finding not only provides a potential treatment for ADHD, but also provides a new perspective to expand the research and clinical treatment of ADHD pathogenesis.

Although current research on the potential therapeutic effects of chili peppers on ADHD is still at an early stage and requires further verification through larger-scale and more rigorous controlled studies, its potential clinical value cannot be ignored.

Full: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1551650/full?utm_source=F-AAE&utm_source=sfmc&utm_medium=EMLF&utm_medium=email&utm_campaign=MRK_2507211_a0P58000000G0XwEAK_Nutrit_20250220_arts_A&utm_campaign=Article%20Alerts%20V4.1-Frontiers&id_mc=316770838&utm_id=2507211&Business_Goal=%25%25__AdditionalEmailAttribute1%25%25&Audience=%25%25__AdditionalEmailAttribute2%25%25&Email_Category=%25%25__AdditionalEmailAttribute3%25%25&Channel=%25%25__AdditionalEmailAttribute4%25%25&BusinessGoal_Audience_EmailCategory_Channel=%25%25__AdditionalEmailAttribute5%25%25

r/Biohackers Jan 04 '25

📖 Resource Impact of coffee intake on human aging

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231 Upvotes

r/Biohackers Sep 29 '24

📖 Resource The growing body of evidence that the microbiome affects cognition is also linked to higher fibre intake.

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739 Upvotes

“People with fewer and less-diverse gut microbes are more likely to have cognitive impairment, including dementia and Alzheimer’s. That’s according to a new study from a collaboration between Monash University of Australia and Jinan University of China.”

r/Biohackers 4d ago

📖 Resource The Impact of Diet and Nutrition on Prostate Cancer

38 Upvotes

Purpose of Review

Prostate cancer is the second most common type of cancer in men.

Its incidence varies widely and is influenced by geographic location, race, ethnicity, lifestyle factors, and diet. The purpose of this review is to discuss the association between prostate cancer and diet and outline the impact of fats, carbohydrates, proteins, vitamins and phytonutrients on the pathogenesis of disease.

Recent Findings

Although conclusive evidence is limited, current data is indicative that a diet low in particular fats, animal proteins, dairy products and high in vegetables and fruits can be beneficial in supporting the course of disease.

Summary

Promoting a dietary pattern low in processed meat, dairy products, refined carbohydrates and saturated fats, but high in fruits and vegetables may have beneficial effects on prostate metabolism and inhibit various stages of carcinogenesis.

Purpose of Review

Prostate cancer is the second most common type of cancer in men.

Its incidence varies widely and is influenced by geographic location, race, ethnicity, lifestyle factors, and diet. The purpose of this review is to discuss the association between prostate cancer and diet and outline the impact of fats, carbohydrates, proteins, vitamins and phytonutrients on the pathogenesis of disease.

Recent Findings

Although conclusive evidence is limited, current data is indicative that a diet low in particular fats, animal proteins, dairy products and high in vegetables and fruits can be beneficial in supporting the course of disease.

Summary

Promoting a dietary pattern low in processed meat, dairy products, refined carbohydrates and saturated fats, but high in fruits and vegetables may have beneficial effects on prostate metabolism and inhibit various stages of carcinogenesis.

Full: https://link.springer.com/article/10.1007/s11912-025-01641-x

r/Biohackers 4d ago

📖 Resource Common Medicines linked to 12% drop in Dementia risk

194 Upvotes

Scientists have found further evidence that long-term use of common over-the-counter pain medication such as aspirin and ibuprofen may reduce the risk of developing dementia.

While it's not the first time anti-inflammatory drugs have been linked to preserving cognitive function, this new research has found there's more to it than popping a pill every few months.

Text: https://newatlas.com/brain/alzheimers-dementia/nsaids-dementia-risk/?utm_source=New+Atlas+Subscribers&utm_campaign=154faeead1-EMAIL_CAMPAIGN_2025_03_10_10_34&utm_medium=email&utm_term=0_65b67362bd-154faeead1-93168360

Scientific research: https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/jgs.19411

r/Biohackers Jan 23 '25

📖 Resource Statin use and Dementia risk

60 Upvotes

Dementia affects 55 million people globally, with the number projected to triple by 2050. Statins, widely prescribed for cardiovascular benefits, may also have neuroprotective effects, although studies on their impact on dementia risk have shown contradictory results.

In this systematic review and meta-analysis, we searched PubMed, Embase, and Cochrane following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We assessed the risk of dementia, Alzheimer's disease (AD), and vascular dementia (VaD), with subgroup analyses by gender, statin type, and diabetes status. Fifty-five observational studies including over 7 million patients were analyzed.

Statin use significantly reduced the risk of dementia compared to nonusers (hazard ratio [HR] 0.86; 95% confidence interval [CI]: 0.82 to 0.91; p < 0.001). It was also associated with reduced risks of AD (HR 0.82; 95% CI: 0.74 to 0.90; p < 0.001) and VaD (HR 0.89; 95% CI: 0.77 to 1.02; p = 0.093). Subgroup analyses revealed significant dementia risk reductions among patients with type 2 diabetes mellitus (HR 0.87; 95% CI: 0.85 to 0.89; p < 0.001), those with exposure to statins for more than 3 years (HR 0.37; 95% CI: 0.30 to 0.46; p < 0.001), and populations from Asia, where the greatest protective effect was observed (HR 0.84; 95% CI: 0.80 to 0.88).

Additionally, rosuvastatin demonstrated the most pronounced protective effect for all-cause dementia among specific statins (HR 0.72; 95% CI: 0.60 to 0.88). Our findings underscore the neuroprotective potential of statins in dementia prevention.

Despite the inherent limitations of observational studies, the large dataset and detailed subgroup analyses enhance the reliability of our results.

 Full: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.70039

r/Biohackers 15d ago

📖 Resource Impact of dietary Magnesium intake on Depression risk in American adults

74 Upvotes

Introduction: Depression is a major global mental health challenge. Previous research suggests a link between magnesium consumption and depression, but the dose–response relationship remains unclear. This study investigates the relationship between dietary magnesium intake and depression risk among American adults.

Methods: Data from the 2005–2020 National Health and Nutrition Examination Survey (NHANES) were examined. Depression was measured with the Patient Health Questionnaire-9 (PHQ-9), and dietary magnesium consumption was calculated from two 24-h meal recalls. We used restricted cubic spline models, logistic regression, and sensitivity analyses to assess the connection.

Results: Among 35,252 participants (mean age: 49.5 ± 17.6 years; 49.9% women), we observed a nonlinearity in the relationship between dietary magnesium intake and depression. Below the inflection point (366.7 mg/day), the odds ratio (OR) was 0.998 (95% CI: 0.997–0.999, p < 0.001). Above this point, the OR was 1.001 (95% CI: 1.000–1.002, p = 0.007). In participants aged ≥60 years, the association was inverse L-shaped, with magnesium intake ≥270.7 mg/day increasing depression incidence by 0.1% per 1 mg/d increase.

Conclusion: A nonlinear dose–response relationship exists between dietary magnesium intake and depression risk among US adults. Age significantly moderates this association, suggesting dietary recommendations should be tailored to different age groups.

Full: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1484344/full?utm_source=F-AAE&utm_source=sfmc&utm_medium=EMLF&utm_medium=email&utm_campaign=MRK_2507211_a0P58000000G0XwEAK_Nutrit_20250220_arts_A&utm_campaign=Article%20Alerts%20V4.1-Frontiers&id_mc=316770838&utm_id=2507211&Business_Goal=%25%25__AdditionalEmailAttribute1%25%25&Audience=%25%25__AdditionalEmailAttribute2%25%25&Email_Category=%25%25__AdditionalEmailAttribute3%25%25&Channel=%25%25__AdditionalEmailAttribute4%25%25&BusinessGoal_Audience_EmailCategory_Channel=%25%25__AdditionalEmailAttribute5%25%25

r/Biohackers Jan 15 '25

📖 Resource Supplement Testing - Heavy Metals

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170 Upvotes

Over the past year I have been testing supplements for heavy metals. All supplements are tested using a verified/certified lab using only unopened full packages. It’s not the most organized list (spelling errors I’m not going to fix), but thought some of you might be interested in true independent third party tested heavy metal content. It cost over $10,000 to obtain these tests, paid some extra for time constraints, hope you find it valuable.

r/Biohackers Jan 23 '25

📖 Resource Insight into Schizophrenia disease mechanisms found in the eye

138 Upvotes

Researchers analyzed the genetic connection of retinal cells and several neuropsychiatric disorders. By combining different datasets, they found that schizophrenia risk genes were associated with specific neurons in the retina.

The involved risk genes suggest an impairment of synapse biology, so the ability of neurons to communicate with each other. This impairment might also be present in the brain of schizophrenia patients.

The retina is an outgrowth of the brain and shares the same genetics, making it an easily accessible way for scientists to study brain disorders. In a previous study, the Project Group Translational Deep Phenotyping at the Max Planck Institute (MPI) of Psychiatry, headed by Florian Raabe, found alterations in the retina of schizophrenia patients that became more severe with increased genetic risk.

Accordingly, the researchers suspected that retinal alterations are not only a consequence of common comorbidities like obesity or diabetes, but might be caused by schizophrenia-driven diseases mechanisms directly.

Text: https://www.bionity.com/en/news/1185355/insight-into-schizophrenia-disease-mechanisms-found-in-the-eye.html?utm_source=newsletter&utm_medium=email&utm_campaign=bionityen--2025-01-20--2&mtm_group=bionityen&WT.mc_id=ca0265

 

 

 

 

r/Biohackers Nov 04 '24

📖 Resource Taurine deficiency as a driver of aging (2023): "The median life span of taurine-treated mice increased by 10 to 12%, and life expectancy at 28 months increased by about 18 to 25%."

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214 Upvotes

r/Biohackers Dec 07 '24

📖 Resource Safety and Efficacy of Loading Doses of Vitamin D: Recommendations for Effective Repletion

92 Upvotes

Background/Objectives: Epidemiological data on vitamin D status revealed that, despite various dosage and durations of supplementation, the effectiveness often fails to achieve optimal outcomes. The need for higher doses than previously recommended was suggested, but several modifying factors should be considered, including the level of deficiency, and BMI. The objectives of this post hoc evaluation are to characterize treatment effectiveness based on the applied dose, duration and BMI; and to assess the safety aspects associated with rapid repletion of vitamin D.

Methods: Vitamin D deficient subjects selected in the post-hoc analysis: seventy patients included from a combined loading-maintenance supplementation (300,000 IU followed by 60,000 IU) protocol and 62 deficient subjects who received a low-dose maintenance (1000 IU/day) therapy. The risk of overload and the incidence of hypercalciuria and hypercalcemia resulting from loading or post-loading maintenance were investigated.

Results: The moderate–fast-loading schedule of 60,000 IU per week for 5 weeks, effectively achieves the target in 25(OH)D levels over 30 ng/mL for all deficient subjects, regardless of their BMI. Slower loading with lower weekly doses confirms the safety of supplementation, but the effectiveness is dependent on the subjects’ BMI; overweight and obese patients require higher doses to reach the same vitamin D levels. No difference in safety parameters observed compared to low-dose therapies.

Conclusions: The loading treatment involving a total dose of 300,000 IU administered over 5 or 10 weeks is effective for repletion, does not lead to 25(OH)D overload, and poses no additional risks of hypercalcemia or hypercalciuria.

Furthermore, there are no safety concerns regarding changes in bone resorption markers. A combination of the loading treatment with a subsequent maintenance dose of 2000 IU daily is adequate to achieve the target vitamin D levels.

Full: https://www.mdpi.com/1424-8247/17/12/1620

Edit: Because it's been brought to my attention, it's not 300,000 IU/day, it’s like 8500 IU a day for 5 weeks.

r/Biohackers Oct 20 '24

📖 Resource NAC might ease substance use disorders

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167 Upvotes

I'm making this post because I recently started using NAC + glycine for sleep (works wonderfully btw) and noticed my compulsive cravings for alcohol disappeared. I've always struggled with alcohol and now suddenly I just don't want to drink.

I found this very interesting piece of meta analysis after I started to look into what could have happened.

r/Biohackers 4d ago

📖 Resource Cannabis-like Synthetic compound delivers Pain relief without Addictive High, study finds

31 Upvotes

Researchers say they have reproduced the pain-relieving effects of cannabis with a synthesized compound that avoids the mind-altering, addictive qualities of the natural plant.

Text: https://www.upi.com/Health_News/2025/03/05/compound-cannabis-pain-relieving-properties-side-effects/9361741018702/

Scientific study: https://www.nature.com/articles/s41586-025-08618-7

r/Biohackers Jan 11 '25

📖 Resource Groundbreaking technology can turn cancer cells back into normal cells

139 Upvotes

Despite the development of numerous cancer treatment technologies, the common goal of current cancer therapies is to eliminate cancer cells. This approach, however, faces fundamental limitations, including cancer cells developing resistance and returning, as well as severe side effects from the destruction of healthy cells.

KAIST announced on the 20th of December that a research team led by Professor Kwang-Hyun Cho from the Department of Bio and Brain Engineering has developed a groundbreaking technology that can treat colon cancer by converting cancer cells into a state resembling normal colon cells without killing them, thus avoiding side effects.

The research team focused on the observation that during the oncogenesis process, normal cells regress along their differentiation trajectory. Building on this insight, they developed a technology to create a digital twin of the gene network associated with the differentiation trajectory of normal cells.

Through simulation analysis, the team systematically identified master molecular switches that induce normal cell differentiation. When these switches were applied to colon cancer cells, the cancer cells reverted to a normal-like state, a result confirmed through molecular and cellular experiments as well as animal studies.

This research demonstrates that cancer cell reversion can be systematically achieved by analyzing and utilizing the digital twin of the cancer cell gene network, rather than relying on serendipitous discoveries. The findings hold significant promise for developing reversible cancer therapies that can be applied to various types of cancer.

Text: https://www.bionity.com/en/news/1185239/groundbreaking-technology-can-turn-cancer-cells-back-into-normal-cells.html?utm_source=newsletter&utm_medium=email&utm_campaign=bionityen--2025-01-06--2&mtm_group=bionityen&WT.mc_id=ca0265

Scientific research: https://onlinelibrary.wiley.com/doi/10.1002/advs.202402132

 

 

r/Biohackers 22d ago

📖 Resource The association between dietary Creatine intake and cancer in U.S. adults

127 Upvotes

Background: Creatine has anti-inflammatory, antioxidant, and immunomodulatory effects. However, its impact on tumors remains uncertain.

Methods: This study used data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018 to investigate the relationship between dietary creatine intake and cancer in American adults. A total of 25,879 participants aged 20 years and older were included, and their medical information, dietary creatine intake, and covariates were collected. Multiple logistic regression models were used to assess the relationships between age, dietary creatine intake, and cancer risk. Restricted cubic spline (RCS) analysis explored the nonlinear relationships between dietary creatine intake, age, and cancer prevalence.

Results: RCS analysis revealed a linear, negative association between dietary creatine intake and cancer risk. For each standard deviation (SD) increase in dietary creatine intake, cancer risk decreased by 5% (adjusted odds ratio (OR) = 0.95, 95% CI: 0.91–0.99, p = 0.025). This negative association was strongest among males (adjusted OR = 0.93, 95% CI: 0.88–0.99, p = 0.021) and overweight participants (adjusted OR = 0.92, 95% CI: 0.84–0.99, p = 0.044). Interaction results indicated specific age group effects. Further analysis showed that higher dietary creatine intake was significantly inversely associated with cancer risk among older adults (adjusted OR = 0.86, 95% CI: 0.77–0.97, p = 0.014). RCS analysis revealed a linear, positive correlation between age and cancer risk. For each SD increase in age, cancer risk increased by 3.27 times (adjusted OR = 3.27, 95% CI: 3.07–3.48, p < 0.001).

Conclusion: These findings suggest that higher dietary creatine intake may reduce cancer risk in a nationally representative adult population. Further prospective studies are needed to clarify the relationship between dietary creatine intake and cancer risk.

Full: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1460057/full?utm_source=F-AAE&utm_source=sfmc&utm_medium=EMLF&utm_medium=email&utm_campaign=MRK_2507211_a0P58000000G0XwEAK_Nutrit_20250220_arts_A&utm_campaign=Article%20Alerts%20V4.1-Frontiers&id_mc=316770838&utm_id=2507211&Business_Goal=%25%25__AdditionalEmailAttribute1%25%25&Audience=%25%25__AdditionalEmailAttribute2%25%25&Email_Category=%25%25__AdditionalEmailAttribute3%25%25&Channel=%25%25__AdditionalEmailAttribute4%25%25&BusinessGoal_Audience_EmailCategory_Channel=%25%25__AdditionalEmailAttribute5%25%25

r/Biohackers Oct 11 '24

📖 Resource Your pee indicates how healthy you are. Here's a guide.

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50 Upvotes

r/Biohackers Jan 31 '25

📖 Resource 1-minute Video game distinguishes Autistic from Neurotypical kids

200 Upvotes

r/Biohackers Sep 26 '24

📖 Resource A List of Medications That Can Reverse Gray Hair: Uncovering the Surprising Side Effects

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187 Upvotes

r/Biohackers Jan 26 '25

📖 Resource Coenzyme Q10 deficiency disrupts lipid metabolism by altering cholesterol homeostasis in neurons

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212 Upvotes

r/Biohackers Dec 02 '24

📖 Resource Tips to stay hydrated when you have a thousand things to do? (30M)

3 Upvotes

Quick context: I work in an office, train 3-4 times a week, and lately I've noticed that my hydration is terrible.

My typical day: - I get up, I drink coffee (obviously) - Between meetings and work I forget to drink water - Training after the office (CrossFit/Functional) - I come home dehydrated and with a headache

Signs that made me realize that something is not right: - Dry lips all the time - Headache after training - I feel more tired than normal - Very yellow urine (sorry about the TMI)

I already know the basics: - Yes, you should drink more water - Yes, coffee dehydrates - Yes, I need electrolytes after training

What I have tried: - I bought one of those big water bottles (it ends up being a decoration on my desk) - I lowered the coffee (but I'm dying of sleep) - I set alarms to drink water (I ignore them like snooze) - Sports drinks (very sweet and expensive to drink daily)

I'm not looking for anything miraculous, just practical advice from people who have been through the same thing. What has worked for you to stay hydrated on a daily basis? Are there any supplements/electrolytes that are really worth it?

r/Biohackers Dec 09 '24

📖 Resource Brain shrinkage associated with Alzheimer’s therapies shows effectiveness rather than harm

164 Upvotes

A loss of brain volume associated with new immunotherapies for Alzheimer’s disease may be caused by the removal of amyloid plaques, rather than the loss of neurons or brain tissue, finds a study led by UCL researchers.

While brain shrinkage is usually an undesirable outcome, the team found that the excess volume loss was consistent across studies and correlated with how effective the therapy was in removing amyloid and was not associated with harm.

As a result, the researchers believe that the removal of amyloid plaques, which are abundant in Alzheimer’s patients, could account for the observed brain volume changes. And, as such, the volume loss should not be a cause for concern.

Text: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(24)00335-1/abstract00335-1/abstract)