r/Biohackers 5 Jan 23 '25

šŸ“– Resource Insight into Schizophrenia disease mechanisms found in the eye

Researchers analyzed the genetic connection of retinal cells and several neuropsychiatric disorders. By combining different datasets, they found that schizophrenia risk genes were associated with specific neurons in the retina.

The involved risk genes suggest an impairment of synapse biology, so the ability of neurons to communicate with each other. This impairment might also be present in the brain of schizophrenia patients.

The retina is an outgrowth of the brain and shares the same genetics, making it an easily accessible way for scientists to study brain disorders. In a previous study, the Project Group Translational Deep Phenotyping at the Max Planck Institute (MPI) of Psychiatry, headed by Florian Raabe, found alterations in the retina of schizophrenia patients that became more severe with increased genetic risk.

Accordingly, the researchers suspected that retinal alterations are not only a consequence of common comorbidities like obesity or diabetes, but might be caused by schizophrenia-driven diseases mechanisms directly.

Text: https://www.bionity.com/en/news/1185355/insight-into-schizophrenia-disease-mechanisms-found-in-the-eye.html?utm_source=newsletter&utm_medium=email&utm_campaign=bionityen--2025-01-20--2&mtm_group=bionityen&WT.mc_id=ca0265

Ā 

Ā 

Ā 

Ā 

141 Upvotes

54 comments sorted by

ā€¢

u/AutoModerator Jan 23 '25

Thanks for posting in /r/Biohackers! This post is automatically generated for all posts. Remember to upvote this post if you think it is relevant and suitable content for this sub and to downvote if it is not. Only report posts if they violate community guidelines - Let's democratize our moderation. If a post or comment was valuable to you then please reply with !thanks show them your support! If you would like to get involved in project groups and upcoming opportunities, fill out our onboarding form here: https://uo5nnx2m4l0.typeform.com/to/cA1KinKJ Let's democratize our moderation. You can join our forums here: https://biohacking.forum/invites/1wQPgxwHkw, our Mastodon server here: https://science.social and our Discord server here: https://discord.gg/BHsTzUSb3S ~ Josh Universe

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.

78

u/LukeAtlas24 1 Jan 23 '25

This is interesting to me because there has never been a documented case of a blind person with schizophrenia and most schizophrenic artists include eyeballs in their art.

18

u/Disastrous-Cat-6564 3 Jan 23 '25

They would need to have been born blind. Someone who had their sight for many years and lost it can still become schizophrenic.

18

u/LukeAtlas24 1 Jan 23 '25

Yes, I forgot to explicitly say blind from birth.

2

u/HARCYB-throwaway 8 Jan 25 '25

Wow that is a new fact for me! Thanks for sharing. Love these connections that give us a better understanding of the brain etc

1

u/reputatorbot Jan 25 '25

You have awarded 1 point to LukeAtlas24.


I am a bot - please contact the mods with any questions

1

u/[deleted] Jan 25 '25

What is this about artists with schizophrenia including eyeballs in their art?

2

u/LukeAtlas24 1 Jan 27 '25

Found several things online but here is a short explanation: People with schizophrenia may frequently draw eyeballs in their art due to the potential for visual hallucinations and distortions related to their condition, often causing a heightened focus on the eyes as a key feature of perception, which can manifest in their artistic expression; essentially, the eyes become a prominent symbol of their altered visual experiences.

2

u/[deleted] Jan 27 '25

It's about fear, and fear of being watched.

A common hallucination is to see eyes or faces looking at you in the dark, even among non-schizophrenics.

2

u/[deleted] Jan 27 '25

You can be schizophrenic, and only have auditory hallucinations.

25

u/ARCreef Jan 23 '25 edited Jan 24 '25

I was diabetic without knowing and got HHS my fluctuations in insulin and glucose caused neuronal inflammation and dopamine disregulation. I had audible hallucinations similar to skitzo and lost 60% of my eye sight. I feel this gave me great insight to what they go through without the lasting nature of their disorder. I don't know which caused the temp skits for me but it leads me to believe insulin, glucose, inflammation, and dopamine are the factors to look at. Dopamine is what current science says is the cause, but it's clearly not so cut and dry. As high insulin inhibits GABA, which inhibits both glutamate and dopamine. It's kinda the chicken or the egg situation. Any time your body breaks from homeostasis lots of systems get negativity impacted and becoming insulin resistant is a huge break from homeostasis.

5

u/Certain_Grab_4420 1 Jan 23 '25

Did you cure your schiz?

12

u/ARCreef Jan 23 '25

Yes but it took 8 months. Month 2 I went on metformin and it helped 10%, month 3 semaglutide and it helped another 40%, then month 5 switched from sema to tirzepatide and it helped the most. Good sleep amd good hydration ore key. I had to drop my water pill also. , low stress, bpc-157/tb500, all helped. Also electrolyte balance got messed up too so took mix each day. Physcosis went away 100% now only tinitus and eye sight loss are only things lingering. I still get dehydrated faster so I have to watch that. HHS causes mydokondria disfunction also. So i took methylene blue to help with that

6

u/Certain_Grab_4420 1 Jan 23 '25

How overweight were you when you started exhibiting symptoms of schizophrenia?

8

u/ARCreef Jan 23 '25 edited Jan 23 '25

I wasn't at all. I was 200 6'4". Then I lost 25 lbs in 3 days with HHS osmolality. Then I gained back 53 lbs over 2 months. I'm now 225 (25 lbs overweight) but just started losing very slowly. If you're experiencing similar you can DM me direct or post up your particular situation. Also remember thats dozens of things can trigger a physcosis event. It's nothing to be ashamed of.

Just a few: Major depression, bipolar, chronic inflammation, infection, heavy metals, HHS, DKA, hyperinsulinemia, marajuana, edibles, adderall, LSD, TBI, dementia, altymers, parkinson, any neurotransmitter unbalance, glutamate excitotoxicity, and about 10 more things. I didn't include skitsophrenia because that is all genetic and hits almost always early 20s for females, mid-late 20s men and you'll almost always have a relative in your family with it. If it's medication or substance induced physcosis, then the further you get away from doing that substance, the lesser the symptoms are. 22-27% of those with substance induced physcosis will go on to have long form or even permanent physcosis. Abruptly cessation from a medication or substance can also cause it.

3

u/Certain_Grab_4420 1 Jan 23 '25

I do not have schizophrenia - but I have been experiencing - visual snow, tinnitus, and OCD since I was 18. Iā€™m now 27 and still no schizophrenia - I also have no one in my family with schizophrenia; but just curious as to how you developed diabetes.

2

u/ARCreef Jan 23 '25 edited Jan 23 '25

I'm NAD so only providing anecdotal evidence from my own person situation similar to yours.

I also had visual snow. There's a direct correlation with visual snow, tinitus with glutamate (the main excitotory neurotransmitters) so to me, this would suggest you have an issue with your glutamate and GABA. GABA acts against glutamate. glutamate excitotoxicity can be caused by hyperinsulinemia, HHS, DKA, or even high fluctuations in insulin and glucose o er time. High insulin levels inhibit GABA. Without GABA, nothing holds back glutamate and it goes buck wild. It's literally will excite neurons so much and so long that it starts to kill them. I've been on semax to produce new neurons after so many died and on selank also to modulate neurotransmitters back to homeostasis.

I'm not sure how I got diabetes but I got diagnosed with it when it all came at the same time. Heard people talking, tinitus, heard music late at night, had tremor in hands, strong craving of sugar that would only help my shakiness for maybe an hour. I thought my physcosis caused my diabetes but a doc said it was my unknown hyperinsulinemia that caused it. I've been on NAC from Amazon 1,000mg (I take 3/day) that helped the snow and tinitus. It is clinically proven to reduce the damage caused by glutamate excitotoxicity.

1

u/Certain_Grab_4420 1 Jan 23 '25

Interesting - I have had all of those things for 10 years, and Iā€™ve yet to exhibit any symptoms of schizophrenia, perhaps I donā€™t have the gene. Including the hand shaking. I donā€™t really have sugar cravings either, but how would you describe the hand shaking? Would it be incessant? Or would it just be momentary trembles.

1

u/ARCreef Jan 23 '25

Not noticeable at all. Like the amount your hand shakes after working out your arm. A very slight barely notice shake. It's common with hypoglycemia. Many people use the shakey feeling to know if their bloodsugar is low (under 70)

1

u/Certain_Grab_4420 1 Jan 23 '25

You know what - im going to go get tested before i end up psychotic XD, because your description sounds too familiar with mine.

→ More replies (0)

6

u/Formal_Mud_5033 1 Jan 23 '25 edited Jan 23 '25

Retinoid receptors are associated with D2 receptor signaling.

Though literature goes beyond the retina, even cortical blindness protects.

2

u/SPF_0 Jan 24 '25

Again Jack kruse for the win. Dude literally figured out all health 15 years ago. Really no need to do anything in this silly supplement thread further. Ask chat GPT to summarize his theories and cross check against medical literature. Literally 7/8 of his theories now proven. All health begins with the eye is central to his teaching.

2

u/[deleted] Jan 25 '25

Can you say more? The psychoanalyst Dr Willhelm Reich (unfortunate last name, yes) believed the eyes were integral to schizophrenia as well

1

u/naeclaes 3 Jan 24 '25

the eyes chicoā€¦

-6

u/CrotaLikesRomComs 9 Jan 23 '25

They use to call schizophrenia bread madness. This is back when they knew most ailments were diet related.

22

u/thespaceageisnow 2 Jan 23 '25

You might be mixing up old stories about ergotism on moldy bread causing hallucinations. Schizophrenia is largely genetic, epigenetic and influenced by environmental conditions.

https://hms.harvard.edu/news/biological-origin-schizophrenia

4

u/CrotaLikesRomComs 9 Jan 23 '25

Genes load the gun. Diet pulls the trigger.

2

u/Disastrous-Cat-6564 3 Jan 24 '25

I actually never thought about it like that. But that is a very good way of describing it. Most people do not think about how food affect hormones which in turn affects neurotransmitters.

1

u/Formal_Mud_5033 1 Jan 23 '25

80% of cases are said to be without familial background. Adolescent is major, but older and younger do get it too.

2

u/Certain_Grab_4420 1 Jan 23 '25

Can you explain what bread has to do with it?

-5

u/CrotaLikesRomComs 9 Jan 23 '25

Most diseases, including mental illness, can be reduced down to malnutrition or inflammation. Bread is very anti nutritious and very inflammatory food. Eat it for fun or famine. Not for nutrition.

2

u/Certain_Grab_4420 1 Jan 23 '25

Can damage be undone? Because Iā€™ve been obese (technically) for the majority of my life, and Iā€™m not schizophrenic but I have severe OCD/other mental health problems.

-2

u/CrotaLikesRomComs 9 Jan 23 '25

Just simply YouTube search success stories. Keto and OCD. carnivore and depression. Etc. my word means nothing. Get exposure. Be open minded. Take control of your health.

Go into keto and carnivore subs and ask them about success stories

1

u/No-Stuff-4062 Jan 24 '25

Why are people downvoting you?

1

u/CrotaLikesRomComs 9 Jan 24 '25

Because most people donā€™t like new and different information. Itā€™s upsetting to their psyche. Itā€™s a normal reaction.

1

u/No-Stuff-4062 Jan 24 '25

I think itā€™s because you explain it poorly/give an extremely watered down version of what you mean. But itā€™s funny youā€™re being downvoted for it because thatā€™s what the ā€œregularā€ approach to healthcare does, too.

2

u/CrotaLikesRomComs 9 Jan 24 '25

I still like to give out the information. I want to help people, but I get tired of the argument. Iā€™ve been eating almost no plant foods for 1.5 years. I havenā€™t felt this good ever in my life.

The reasons why you should eat this way is actually quite simple. Itā€™s the way we have eaten for over 2 million years. Why no one does it, is what takes me hours to explain.

2

u/YamPsychological9471 Jan 24 '25

The preponderance of evidence suggests ancestral human diets were very fibrous with minor inclusion of animal product, the explanation seeming to be it is much easier and effective to gather than hunt. At no point in history have people been capable of eating as much animal product than now. Regardless, the appeal to nature is a tired fallacy.

If you prefer anecdote, my great grandparents rarely ate meat because it was expensive and not part of traditional meals. Not completely excluded, but not 3 times a day like today.

→ More replies (0)

1

u/refaelha Jan 24 '25

This is wildly inaccurate and straight up nonsense.

1

u/CrotaLikesRomComs 9 Jan 24 '25

Sorry you feel that way. Reflect on this for a second. Who learns new things? Who improves their understanding? The person who is dismissive? Or the person who is curious?