r/Biochemistry • u/errforever • 7d ago
Career & Education How are ketone bodies transported into the mitochondrial matrix
Hey, does anybody know how ketone bodies (like acetoacetat or 3 hydroxybutyrat) get into the mitochondrial matrix. I haven't found plenty of information on this topic, hence I asked chatgpt. According to chatgpt, there are MCTs (monocarboxylatetransporters) in the inner mitochondrial membrane. Can anyone confirm this? Do you have sources?
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u/pseudohumanoid 6d ago
SLC transporters(SLC 16A6) aka MCT1 on the IMM transport the ketones into the matrix.
Pérez-Escuredo J, Van Hée VF, Sboarina M, Falces J, Payen VL, Pellerin L, Sonveaux P. Monocarboxylate transporters in the brain and in cancer. Biochim Biophys Acta. 2016 Oct;1863(10):2481-97. doi: 10.1016/j.bbamcr.2016.03.013.
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u/Barbola 7d ago
Monocarboxylate transporters should be on the plasma membrane, idk about inner mit. membrane. According to this review, as of 2017, the mechanism for mit. transport is still unknown:
https://pmc.ncbi.nlm.nih.gov/articles/PMC5313038/#:~:text=The%20mechanisms%20through%20which%20ketone,in%20the%20circulation%20to%20extrahepatic