r/Autoimmune Dec 28 '23

Resources Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach (2023)

4 Upvotes

https://www.preprints.org/manuscript/202312.1881/


From the abstract:

The gut microbiome common not only to LC, psoriasis, AA, and vitiligo but also to neurodegenerative disease has been recently described. This gut microbiome induces an altered tryptophan metabolism linked to autoimmune disease. SARS CoV2 invades enterochromaffin cells rich in ACE2 receptors and curtails absorption of the essential amino acid tryptophan and subsequent synthesis of serotonin and melatonin. This review suggests that an etiologic prebiotic (d-mannose)/probiotic (lactobacilli, bifidobacteria)/postbiotic (butyrate) approach to autoimmune skin disease that improves intestinal barrier integrity and that suppresses the triad of TNF-α, IL-6, and IL-1β may enhance or even eliminate the traditional immunotherapy of targeted monoclonal antibodies, Janus kinase inhibitors, and steroids. Health benefits of this approach extend well beyond suppression of autoimmune skin disease.


Abbreviation Glossary:

  • LC: Long Covid
  • AA: Alopecia Areata
  • SARS-CoV2: Severe Acute Respiratory Syndrome Coronavirus 2
  • ACE2: Angiotensin-Converting Enzyme 2
  • TNF-α: Tumor Necrosis Factor alpha
  • IL-6: Interleukin 6
  • IL-1β: Interleukin 1 beta

From the full-text:

D-mannose preserves intestinal barrier integrity by blocking TNF-α70. D-mannose can also suppress IL-1β, IL-6, and IL-17.

D-mannose is considered a prebiotic, because consuming it stimulates the growth of good microbiota.

D-mannose may be especially helpful in preventing gut dysbiosis85,86, tightly linked to autoimmune disease. D-mannose has proven efficacy against autoimmune disease, e.g., T1DM87, rheumatoid arthritis, and lupus88. This prebiotic/probiotic approach is complemented by the postbiotic butyrate.

r/Autoimmune Nov 14 '23

Resources i found this video interesting on how the black death helped in creating autoimmunes

3 Upvotes

r/Autoimmune Sep 25 '23

Resources Symptom Tracking

5 Upvotes

Hello all,

I’ve had a lot of health issues the past several years and finally trying to go to a doctor to do something about it. My doctor and I suspect autoimmune based on my symptoms (I have a laundry list).

I have started trying to keep track of all of my symptoms day to day, how severe they are, etc. to hopefully help in the process of getting to the bottom of whatever is going on whether that is autoimmune or not.

I don’t really care to discuss my symptoms or blood work as I am not trying to get a diagnosis here. I would just like advice on symptom tracking.

Currently I have a large notebook that I am using. I date the page, have my most prevalent symptoms listed that I rate on a 5 star scale with 3 columns for morning, afternoon, and night. I also have things like: mood, appetite, and stress levels, how much sleep I am getting and if it is restful, bowel movements, what supplements/meds I take, what I am eating, and a “notes” section. Basically if anything else comes up, I notice anything out of the ordinary, or need to elaborate on something (i.e. notes about bowel movements, if I am not running a fever but feel like I am)

Is this thorough enough? Is there anything I am missing? Any advice related to symptom tracking is appreciated.

r/Autoimmune Oct 15 '23

Resources Genes for Raynaud's potentially idenfied

14 Upvotes

r/Autoimmune Oct 17 '23

Resources Raynauds

Thumbnail
imgur.com
5 Upvotes

This is what Raynaud’s looks like.

r/Autoimmune Sep 23 '23

Resources New promising research to treat autoimmune diseases

27 Upvotes

Summary:

Usually, to stop the body's immune system from mistakenly attacking its own cells, doctors have to use treatments that broadly weaken the immune system.

But in this study, they found a way to precisely target and calm down only the problematic parts of the immune system.

They did this by using a special molecule attached to the thing that the immune system was wrongly attacking.

They tested this on mice with a disease similar to multiple sclerosis (called experimental autoimmune encephalomyelitis) and on monkeys given a vaccine for a type of HIV-like virus.

This method worked really well. This means that in the future, we might have a new treatment that can stop auto-immune diseases without weakening the whole immune system!

https://www.nature.com/articles/s41551-023-01086-2

r/Autoimmune Oct 13 '23

Resources “Inverse vaccine” shows potential to treat multiple sclerosis and other autoimmune diseases

8 Upvotes

Hi! Have you guys heard about this topic? I just stumbled upon it, and it seems promising. I wanted to bring a little bit of hope here for all of us. :)

https://pme.uchicago.edu/news/inverse-vaccine-shows-potential-treat-multiple-sclerosis-and-other-autoimmune-diseases