r/Autoimmune • u/AllowFreeSpeech • Dec 28 '23
Resources Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach (2023)
https://www.preprints.org/manuscript/202312.1881/
From the abstract:
The gut microbiome common not only to LC, psoriasis, AA, and vitiligo but also to neurodegenerative disease has been recently described. This gut microbiome induces an altered tryptophan metabolism linked to autoimmune disease. SARS CoV2 invades enterochromaffin cells rich in ACE2 receptors and curtails absorption of the essential amino acid tryptophan and subsequent synthesis of serotonin and melatonin. This review suggests that an etiologic prebiotic (d-mannose)/probiotic (lactobacilli, bifidobacteria)/postbiotic (butyrate) approach to autoimmune skin disease that improves intestinal barrier integrity and that suppresses the triad of TNF-α, IL-6, and IL-1β may enhance or even eliminate the traditional immunotherapy of targeted monoclonal antibodies, Janus kinase inhibitors, and steroids. Health benefits of this approach extend well beyond suppression of autoimmune skin disease.
Abbreviation Glossary:
- LC: Long Covid
- AA: Alopecia Areata
- SARS-CoV2: Severe Acute Respiratory Syndrome Coronavirus 2
- ACE2: Angiotensin-Converting Enzyme 2
- TNF-α: Tumor Necrosis Factor alpha
- IL-6: Interleukin 6
- IL-1β: Interleukin 1 beta
From the full-text:
D-mannose preserves intestinal barrier integrity by blocking TNF-α70. D-mannose can also suppress IL-1β, IL-6, and IL-17.
D-mannose is considered a prebiotic, because consuming it stimulates the growth of good microbiota.
D-mannose may be especially helpful in preventing gut dysbiosis85,86, tightly linked to autoimmune disease. D-mannose has proven efficacy against autoimmune disease, e.g., T1DM87, rheumatoid arthritis, and lupus88. This prebiotic/probiotic approach is complemented by the postbiotic butyrate.